Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase [PDF]
iScience, 2023 Summary: Neutrophil swarming is a complex coordinated process in which neutrophils sensing pathogen or damage signals are rapidly recruited to sites of infections or injuries.
Zhimin Song +3 more
doaj +8 more sources
Neutrophil swarming delays the growth of clusters of pathogenic fungi [PDF]
Nature Communications, 2020 Neutrophils employ several mechanisms to control the growth of fungi, including enzymes, reactive oxygen species, extracellular traps, and formation of “swarms”. Here, Hopke et al. study how the different mechanisms work together, using an in vitro assay
Alex Hopke +7 more
doaj +8 more sources
Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi [PDF]
iScience, 2022 Summary: Neutrophil swarming is an emergent host defense mechanism triggered by targets larger than a single neutrophil’s capacity to phagocytose. Swarming synergizes neutrophil functions, including chemotaxis, phagocytosis, and reactive oxygen species ...
Alex Hopke +9 more
doaj +4 more sources
Pioneer neutrophils release chromatin within in vivo swarms [PDF]
eLife, 2021 Neutrophils are rapidly recruited to inflammatory sites where their coordinated migration forms clusters, a process termed neutrophil swarming. The factors that modulate early stages of neutrophil swarming are not fully understood, requiring the ...
Hannah M Isles +13 more
doaj +8 more sources
Neutrophil swarming: Is a good offense the best defense? [PDF]
iScience, 2023 Summary: The phenomenon of swarming has long been observed in nature as a strategic event that serves as a good offense toward prey and predators. Imaging studies have uncovered that neutrophils employ this swarm-like tactic within infected and inflamed ...
Luke Brown, Bryan G. Yipp
doaj +4 more sources
Spleen tyrosine kinase inhibitors disrupt human neutrophil swarming and antifungal functions [PDF]
Microbiology SpectrumNeutrophils communicate with one another and amplify their destructive power through swarming, a collective process that synchronizes the activities of multiple neutrophils against one target.
Alex Hopke +5 more
doaj +4 more sources
Inhibition of neutrophil swarming by type I interferon promotes intracellular bacterial evasion [PDF]
Nature CommunicationsListeria monocytogenes (LM) possesses the ability to breach multiple barriers and elicit intricate immune responses. However, there remains a lack of explicit understanding regarding how LM evades innate immune surveillance within the body.
Shimin Li +9 more
doaj +4 more sources
Publisher Correction: Neutrophil swarming delays the growth of clusters of pathogenic fungi [PDF]
Nature Communications, 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Alex Hopke +7 more
doaj +5 more sources
Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming. [PDF]
Nat Biomed Eng, 2017 Neutrophil swarms protect healthy tissues by sealing off sites of infection. In the absence of swarming, microbial invasion of surrounding tissues can result in severe infections.
Reátegui E +9 more
europepmc +8 more sources
Arp2/3 complex and the pentose phosphate pathway regulate late phases of neutrophil swarming [PDF]
iScienceSummary: Neutrophil swarming is an essential process of the neutrophil response to many pathological conditions. Resultant neutrophil accumulations are hallmarks of acute tissue inflammation and infection, but little is known about their dynamic ...
Katharina M. Glaser +6 more
doaj +6 more sources