Results 91 to 100 of about 2,507 (174)

Myeloid‐Derived CD38 Mediates Age‐Related Endometrial Aging Through NAD+ Depletion

Aging Cell, Volume 25, Issue 1, January 2026.
An increased population of CD38+ macrophages, accompanied by a marked decline in stromal cell NAD+ levels, serves as key hallmarks of endometrial aging in aged mice. Pharmacological and genetic interventions revealed that macrophage‐derived CD38 is a principal driver of uterine NAD+ depletion, thereby accelerating stromal cell senescence and impairing ...
Lun Hua, Luting Liu, Dengfeng Gao, Lulu Ma, Xianyang Jin, Liuyong Lu, Shangbo Tian, Xuemei Jiang, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Long Jin, Yong Zhuo, Mingzhou Li, De Wu   +16 more
wiley   +1 more source

Eradicating, retaining, balancing, swarming, shuttling and dumping: a myriad of tasks for neutrophils during fungal infection

Current Opinion in Microbiology, 2020
Opportunistic, invasive mycoses in immunocompromised patients remain challenging for health care with unacceptably high levels of morbidity and mortality. Neutrophils are essential in host protection against invasive mycoses. Upon development of acute infection, neutrophils are recruited from circulation to the infected tissue, where they exert a ...
Constantin F Urban, Emelie Backman
openaire   +3 more sources

An interpretable machine learning model for predicting metabolic dysfunction‐associated steatotic liver disease in patients with type 2 diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 122-136, January 2026.
Abstract Aim Patients with type 2 diabetes mellitus (T2DM) exhibit an elevated prevalence of metabolic dysfunction‐associated steatotic liver disease (MASLD) and are at greater risk of liver‐related adverse events. Existing non‐invasive tools show limited diagnostic performance in this population.
Zhuolin Zhou, Nan Gao, Jiaojiao Liu, Xuerong Ma, Zhijuan Ge, Cheng Ji   +5 more
wiley   +1 more source

The temperate Burkholderia phage AP3 of the Peduovirinae shows efficient antimicrobial activity against B. cenocepacia of the IIIA lineage [PDF]

, 2016
Burkholderia phage AP3 (vB_BceM_AP3) is a temperate virus of the Myoviridae and the Peduovirinae subfamily (P2likevirus genus). This phage specifically infects multidrug-resistant clinical Burkholderia cenocepacia lineage IIIA strains commonly isolated ...
Briers, Yves, Drulis-Kawa, Zuzanna, Holt, Giles S., Latka, Agnieszka, Lavigne, Rob, Maciejewska, Barbara, Olszak, Tomasz, Roszniowski, Bartosz, Smith, Darren L., Valvano, Miguel A., Vandenheuvel, Dieter   +10 more
core   +2 more sources

Persistent Severe Acute Kidney Injury Among Critically Ill Patients: Outcomes and Predictive Markers—A Single‐Center Retrospective Cohort Study

Critical Care Research and Practice, Volume 2026, Issue 1, 2026.
Background Persistent severe acute kidney injury (PS‐AKI)—recently standardized as Kidney Disease: Improving Global Outcomes (KDIGO) Stage 3 persisting ≥ 72 h, or renal replacement therapy/death after Stage 3 diagnosis—has emerged as a trajectory‐based phenotype complementing conventional KDIGO staging. Evidence in contemporary intensive care unit (ICU)
Tung Phi Nguyen, Thang Trong Khong, Hoai Thi Thu Vu, Nam Ngoc Phuong Nguyen, Phong Van Phan, Hue Thi Le, Tra Thi Hoang, Huyen Thi Nguyen, Loan Thi Phan, Yen Thi Kim Nguyen, Phuong Khanh Nguyen Hoang, Timothy Plackett   +11 more
wiley   +1 more source

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source

MetR-Regulated Vibrio cholerae Metabolism Is Required for Virulence [PDF]

, 2012
LysR-type transcriptional regulators (LTTRs) are the largest, most diverse family of prokaryotic transcription factors, with regulatory roles spanning metabolism, cell growth and division, and pathogenesis.
Bogard, Ryan William, Davies, Bryan William, Mekalanos, John J.   +2 more
core   +1 more source

Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process

Exploration, Volume 5, Issue 6, December 2025.
Periosteum is a key factor in bone regeneration and repair, and the development of periosteum organoids with the help of organoid technology can achieve accelerated bone regeneration. This review explores the structure and function of the periosteum, the design and application of periosteum organoids, and their potential integration with bone organoids,
Shuyue Hao, Fuxiao Wang, Jingtao Huang, Zhidao Xia, James T. Triffitt, Chenjie Xu, Long Bai, Jiacan Su   +7 more
wiley   +1 more source

Targeting deficiencies in the TLR5 mediated vaginal response to treat female recurrent urinary tract infection [PDF]

, 2017
The identification of the host defence peptides as target effectors in the innate defence of the uro-genital tract creates new translational possibilities for immunomodulatory therapies, specifically vaginal therapies to treat women suffering from rUTI ...
AA Ashkar, AL Flores-Mireles, AR Brumbaugh, AS Ali, AS Cass, B Becknell, B Foxman, B Foxman, B Li, BJ Bachmann, CC Rigby, CL Townes, CY Chan, D Vita De, DA Hill, DA Rosen, E Andersen-Nissen, ES Danka, EV Valore, G Gong, G Wlasiuk, GF Dusio, J Rohrl, J Shi, J Song, J Zhao, JA Silverman, K Gupta, K Gupta, KA Hutton, KD Smith, L Robino, M Chromek, MA Beerepoot, MA Handley, MC Lane, NI Paphitou, NJ Smith, NS Savar, O Ciani, P Aldridge, R Kucheria, RA Welch, RE Hancock, RN Fichorova, SJ Hultgren, SJ Klebanoff, SN Abraham, T Ganz, T Klein, TA Stamey, TJ Hannan, TR Hawn, TR Hawn, TR Hawn, V Nienhouse   +55 more
core   +2 more sources

Role of c-di-GMP signalling in bacterial-host interactions [PDF]

, 2010
Bacteria have various ways to sense environmental signals and to adapt their behavior and physiology through different signaling systems. Secondary messenger signaling, amplified by enzymatic activity, rapidly transmits a signal in the cell, resulting in
Lamprokostopoulou, Agaristi
core