Redox processes are major regulators of leukotriene synthesis in neutrophils exposed to bacteria Salmonella typhimurium; the way to manipulate neutrophil swarming [PDF]
Frontiers in ImmunologyNeutrophils play a primary role in protecting our body from pathogens. When confronted with invading bacteria, neutrophils begin to produce leukotriene B4, a potent chemoattractant that, in cooperation with the primary bacterial chemoattractant fMLP ...
Ekaterina A. Golenkina +9 more
doaj +4 more sources
Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity [PDF]
npj Vaccines, 2017 Boosting immunity: How alum NETS improved vaccination Researchers have identified the mechanism of action in which aluminium hydroxide (alum) boosts the efficacy of co-administered vaccines.
J. Stephen +5 more
doaj +6 more sources
Resolvin D1 prevents injurious neutrophil swarming in transplanted lungs. [PDF]
Proc Natl Acad Sci U S A, 2023 Neutrophils are the primary cell type involved in lung ischemia-reperfusion injury (IRI), which remains a frequent and morbid complication after organ transplantation. Endogenous lipid mediators that become activated during acute inflammation-resolution have gained increasing recognition for their protective role(s) in promoting the ...
Li W +8 more
europepmc +4 more sources
Gram-Negative Bacteria Salmonella typhimurium Boost Leukotriene Synthesis Induced by Chemoattractant fMLP to Stimulate Neutrophil Swarming [PDF]
Frontiers in Pharmacology, 2022 Leukotriene synthesis in neutrophils is critical for host survival during infection. In particular, leukotriene B4 (LTB4) is a powerful neutrophil chemoattractant that plays a crucial role in neutrophil swarming.
Ekaterina A. Golenkina +6 more
doaj +2 more sources
Chemotaxis and swarming in differentiated HL-60 neutrophil-like cells [PDF]
Scientific Reports, 2021 The human leukemia cell line (HL-60) is an alternative to primary neutrophils in research studies. However, because HL-60 cells proliferate in an incompletely differentiated state, they must undergo differentiation before they acquire the functional ...
Kehinde Adebayo Babatunde +5 more
doaj +3 more sources
Neutrophils: Amoeboid Migration and Swarming Dynamics in Tissues
Frontiers in Cell and Developmental Biology, 2022 Neutrophils are key cells of our innate immune response with essential roles for eliminating bacteria and fungi from tissues. They are also the prototype of an amoeboid migrating leukocyte.
Michael Mihlan +7 more
doaj +5 more sources
Ex Vivo Human Neutrophil Swarming Against Live Microbial Targets. [PDF]
Methods Mol Biol, 2020 Neutrophils often communicate with each other and coordinate their actions to seal off large sites of injury and infection that individual neutrophils could not cover. The concerted actions of neutrophils are essential for the expeditious protection of healthy tissues from wounds and microbes.
Hopke A, Irimia D.
europepmc +4 more sources
<i>Pseudomonas aeruginosa</i> aggregates elicit neutrophil swarming. [PDF]
iSciencePseudomonas aeruginosa, a gram-negative multidrug-resistant (MDR) opportunist, belongs to the ESKAPE group of pathogens associated with the highest risk of mortality. Neutrophil swarming is a host defense strategy triggered by larger threats, where neutrophil swarms contain and clear damage/infection. Current ex vivo models designed to study neutrophil-
Drenkard E +6 more
europepmc +3 more sources
Neutrophils self-limit swarming to contain bacterial growth in vivo [PDF]
Science, 2021 Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination of bacteria and fungi.
Baumeister, R. +13 more
core +6 more sources
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo [PDF]
Nature, 2013 Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined1,2. Once outside the
Afonso, P. +6 more
core +6 more sources