Results 21 to 30 of about 2,507 (174)

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model. [PDF]

PLoS ONE
Implant-associated osteomyelitis remains a major orthopaedic problem. As neutrophil swarming to the surgical site is a critical host response to prevent infection, visualization and quantification of this dynamic behavior at the native microenvironment ...
Sashank Lekkala, Youliang Ren, Jason Weeks, Kevin Lee, Allie Jia Hui Tay, Bei Liu, Thomas Xue, Joshua Rainbolt, Chao Xie, Edward M Schwarz, Shu-Chi A Yeh   +10 more
doaj   +2 more sources

Sulfur compounds navigate redox processes, leukotriene synthesis, and ω-hydroxylation of leukotriene B4 in neutrophil interaction with the bacteria Salmonella typhimurium: the way to manipulate neutrophil swarming [PDF]

Frontiers in Immunology
Neutrophils are the first immune cells recruited by invading pathogens. During interaction with bacteria, neutrophils synthesize leukotriene B4, a potent chemoattractant that, in conjunction with the primary bacterial chemoattractant N-formyl-l-methionyl-
Ekaterina A. Golenkina, Sofia V. Navarnova, Galina M. Viryasova, Svetlana I. Galkina, Tatjana V. Gaponova, Yulia M. Romanova, Galina F. Sud’ina   +6 more
doaj   +2 more sources

Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming. [PDF]

Dev Cell
Neutrophils collectively migrate to sites of injury and infection. How these swarms are coordinated to ensure the proper level of recruitment is unknown. Using an ex vivo model of infection, we show that human neutrophil swarming is organized by multiple pulsatile chemoattractant waves.
Strickland E, Pan D, Godfrey C, Kim JS, Hopke A, Ji W, Degrange M, Villavicencio B, Mansour MK, Zerbe CS, Irimia D, Amir A, Weiner OD.   +12 more
europepmc   +4 more sources

Neutrophil swarming is crucial for limiting oral mucosal infection by Candida albicans. [PDF]

J Leukoc Biol
Abstract Oral mucosal colonization by Candida albicans is benign in healthy people but progresses to deeper infection, known as oropharyngeal candidiasis, that may become disseminated when combined with immunosuppression. Cortisone use and neutropenia are risk factors for invasive mucosal fungal infections; however, the mechanisms are ...
Saraswat D, Rojas IG, Kumar R, Li R, Salvatori O, Irimia D, Edgerton M.   +6 more
europepmc   +3 more sources

Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals. [PDF]

Curr Biol, 2020
Neutrophils are major inflammatory cells that rapidly infiltrate wounds to provide antimicrobial functions. Within the damaged tissue, neutrophil migration behavior often switches from exploratory patrolling to coordinated swarming, giving rise to dense clusters that further disrupt tissue architecture.
Poplimont H, Georgantzoglou A, Boulch M, Walker HA, Coombs C, Papaleonidopoulou F, Sarris M.   +6 more
europepmc   +3 more sources

Neutrophil swarming toward Cryptococcus neoformans is mediated by complement and leukotriene B4. [PDF]

Biochem Biophys Res Commun, 2016
Swarming behavior of neutrophils has been noticed in both sterile injury and infection models and the mechanisms are being unveiled. So far, no in vitro model has been established to study neutrophil swarming to microbes. In the current study, using live-cell imaging, we observed in vitro neutrophil swarming toward Cryptococcus neoformans, a fungal ...
Sun D, Shi M.
europepmc   +4 more sources

ATG5 suppresses type I IFN-dependent neutrophil swarming and NETosis

, 2023
SUMMARYInflammation is critical for controlling infections, but when left unchecked can cause tissue damage and disease. For tuberculosis, the leading cause of death due to infection1, host inflammation is responsible for the clinical symptoms2, morbidity2, and mortality3,4.
Kinsella RL, Chowdhury CS, Smirnov A, Mreyoud Y, Kimmey JM, Esaulova E, Kreamalmeyer D, Artyomov MN, Stallings CL.   +8 more
europepmc   +2 more sources

Cell migration: Arraying neutrophils in swarms [PDF]

Nature Biomedical Engineering, 2017
Microscale arrays of protein–polysaccharide clusters enable the functional characterization of human-neutrophil ...
Lämmermann, T.
core   +4 more sources

ATP and Formyl Peptides Facilitate Chemoattractant Leukotriene-B4 Synthesis and Drive Calcium Fluxes, Which May Contribute to Neutrophil Swarming at Sites of Cell Damage and Pathogens Invasion [PDF]

Biomedicines
Here, we demonstrate that human neutrophil interaction with the bacterium Salmonella typhimurium fuels leukotriene B4 synthesis induced by the chemoattractant fMLP.
Ekaterina A. Golenkina, Galina M. Viryasova, Svetlana I. Galkina, Iuliia V. Iakushkina, Tatjana V. Gaponova, Yulia M. Romanova, Galina F. Sud’ina   +6 more
doaj   +2 more sources

Caging giants: Characterizing the molecular mechanisms of neutrophil swarming against Candida albicans hyphae. [PDF]

J Leukoc Biol
Abstract Neutrophils utilize many mechanisms to restrict fungal growth. When phagocytosis occurs, neutrophils can create many toxic antimicrobials including reactive oxygen species and the products of myeloperoxidase. If a pathogen is too large to phagocytose, neutrophils can also resort to the release of neutrophil extracellular traps ...
Phillips TK, Lawson K, Ozment TR, Scherer A, Hopke A.   +4 more
europepmc   +2 more sources