Results 31 to 40 of about 2,507 (174)

TNF-α x FcαRI bi-specific antibody potentiates neutrophil-mediated anti-tumor effects [PDF]

Scientific Reports
Immunotherapy has emerged as a promising strategy against cancer, but many patients fail to achieve durable responses. Inefficiency of immunotherapy is often caused by the immunosuppressive tumor microenvironment.
D. Y. Gout, C. A. N. Sewnath, G. Duru, R. van der Mast, C. W. Tuk, A. E. H. Bentlage, M. Gruijs, G. Vidarsson, N. Heemskerk, M. van Egmond   +9 more
doaj   +2 more sources

Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils [PDF]

Frontiers in Immunology
The intermediate filament vimentin is present in immune cells and is implicated in proinflammatory immune responses. Whether and how it supports antimicrobial activities of neutrophils are not well established.
Thao Ngoc Huynh, Jody Toperzer, Allison Scherer, Allison Scherer, Anne Gumina, Tonya Brunetti, Michael K. Mansour, Michael K. Mansour, David M. Markovitz, Brian C. Russo   +9 more
doaj   +2 more sources

Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices

Frontiers in Immunology, 2021
Complement activation is key to anti-microbial defenses by directly acting on microbes and indirectly by triggering cellular immune responses. Complement activation may also contribute to the pathogenesis of numerous inflammatory and immunological ...
Sinan Muldur, Sinan Muldur, Douangsone D. Vadysirisack, Sharan Ragunathan, Yalan Tang, Alonso Ricardo, Camil Elie Sayegh, Daniel Irimia, Daniel Irimia   +8 more
doaj   +1 more source

Exploring the Process of Neutrophil Transendothelial Migration Using Scanning Ion-Conductance Microscopy

Cells, 2023
The dynamics of neutrophil transendothelial migration was investigated in a model of experimental septicopyemia. Scanning ion-conductance microscopy allowed us to determine changes in morphometric characteristics of endothelial cells during this process.
Svetlana N. Pleskova, Nikolay A. Bezrukov, Ekaterina N. Gorshkova, Sergey Z. Bobyk, Ekaterina V. Lazarenko   +4 more
doaj   +1 more source

Analyzing Inter-Leukocyte Communication and Migration In Vitro: Neutrophils Play an Essential Role in Monocyte Activation During Swarming

Frontiers in Immunology, 2021
Neutrophils are known to be the first responders to infection or injury. However, as inflammation progresses, other leukocytes become increasingly important in inflammation propagation, tissue reconstruction, and inflammation resolution. In recent years,
Nicole Walters, Jingjing Zhang, Xilal Y. Rima, Luong T. H. Nguyen, Ronald N. Germain, Tim Lämmermann, Tim Lämmermann, Eduardo Reátegui, Eduardo Reátegui   +8 more
doaj   +1 more source

Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release

iScience, 2023
Summary: Neutrophils are white blood cells that are critical to acute inflammatory and adaptive immune responses. Their swarming-pattern behavior is controlled by multiple cellular cascades involving calcium-dependent release of various signaling ...
Olga Kopach, Sergyi Sylantyev, Lucie Bard, Piotr Michaluk, Janosch P. Heller, Ana Gutierrez del Arroyo, Gareth L. Ackland, Alexander V. Gourine, Dmitri A. Rusakov   +8 more
doaj   +1 more source

Neutrophil Swarms Are More Than the Accumulation of Cells [PDF]

Microbiology Insights, 2020
Neutrophils move from the blood into tissues, migrate under the guidance of chemical gradients, and accumulate at sites of infection, where they phagocytose and kill microbes within minutes. These processes have been considered the keystone of innate immune responses for more than five decades.
openaire   +2 more sources

Loss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, Candida albicans, in Patients With Cirrhosis

Hepatology Communications, 2021
Neutrophils are the most abundant white blood cell in the body and are key participants in the defense against fungal infections. Fungal infections occur often in patients with cirrhosis and are associated with increased 30‐day and 90‐day mortality ...
Sally A.I. Knooihuizen, Natalie J. Alexander, Alex Hopke, Nicolas Barros, Adam Viens, Allison Scherer, Natalie J. Atallah, Zeina Dagher, Daniel Irimia, Raymond T. Chung, Michael K. Mansour   +10 more
doaj   +1 more source

Social interactions in the Burkholderia cepacia complex : biofilms and quorum sensing [PDF]

, 2010
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B.
Coenye, Tom
core   +2 more sources

Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress [PDF]

, 2012
Acknowledgments We thank Alexander Johnson (yhb1D/D), Karl Kuchler (sodD/D mutants), Janet Quinn (hog1D/D, hog1/cap1D/D, trx1D/D) and Peter Staib (ssu1D/D) for providing mutant strains.
A Cederlund, A da Silva Dantas, Alistair J. P. Brown, B Amulic, B Enjalbert, B Enjalbert, B Hube, B Hube, BD Ullmann, Bernhard Hube, BH Youseff, BS Hromatka, C Fradin, Christine Dunker, CJ Barelle, CJ Barelle, CJ Heilmann, D Wilson, DA Smith, DL Moyes, DL Moyes, DM Arana, DR Wysong, FC Fang, GM Chaves, Hanna Windecker, I Rubin-Bejerano, I Wozniok, ID Jacobsen, IE Frohner, Iryna M. Bohovych, J Cheetham, M de Jesus-Berrios, M Martchenko, MA Wheeler, MC Lorenz, MC Lorenz, MG Netea, Oliver Kurzai, Oscar Zaragoza, P Nordenfelt, Pedro Miramón, R Alonso-Monge, R Pathania, RA Calderone, RI Lehrer, SC Cheng, TM Stevanin, TM Stevanin, V Brinkmann, W Bellamy, W Chiranand   +51 more
core   +3 more sources