Results 1 to 10 of about 24,193 (172)

Neutrophils and Asthma

Diagnostics, 2022
Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic inflammation is also marked, and eosinophils and neutrophils can coexist in some cases. Based on the proportion of sputum cell differentiation, asthma is classified
Akira Yamasaki, Ryota Okazaki, Tomoya Harada   +2 more
doaj   +3 more sources

Neuropilin‐2 regulates airway inflammation in a neutrophilic asthma model [PDF]

Immunity, Inflammation and Disease, 2022
Background Asthma is a heterogenous disease that can be classified into eosinophilic (type 2‐high) and noneosinophilic (type 2‐low) endotypes. The type 2‐low endotype of asthma can be characterized by the presence of neutrophilic airway inflammation that
Robert M. Immormino, Corey M. Jania, Stephen L. Tilley, Timothy P. Moran   +3 more
doaj   +2 more sources

Occupational Neutrophilic Asthma [PDF]

Canadian Respiratory Journal, 1999
Occupational asthma is typically associated with an eosinophilic bronchitis. The case of a 41-year-old woman who developed symptoms of asthma after occupational exposure to metal working fluids is reported.
Richard Leigh, Frederick E Hargreave
doaj   +4 more sources

Neutrophilic Asthma Is Associated With Smoking, High Numbers of IRF5+, and Low Numbers of IL10+ Macrophages [PDF]

Frontiers in Allergy, 2021
Asthma is a heterogenous disease with different inflammatory subgroups that differ in disease severity. This disease variation is hampering treatment and development of new treatment strategies.
Nil Turan, T. Anienke van der Veen, T. Anienke van der Veen, Christina Draijer, Christina Draijer, Fatemeh Fattahi, Fatemeh Fattahi, Fatemeh Fattahi, Nick H. ten Hacken, Nick H. ten Hacken, Wim Timens, Wim Timens, Antoon J. van Oosterhout, Maarten van den Berge, Maarten van den Berge, Barbro N. Melgert, Barbro N. Melgert, Barbro N. Melgert   +17 more
doaj   +2 more sources

Airway monocyte modulation relates to tumour necrosis factor dysregulation in neutrophilic asthma [PDF]

ERJ Open Research, 2021
Background Dysregulation of tumour necrosis factor-α (TNF-α) signalling is implicated in neutrophilic asthma. TNF-α signalling involves membrane-bound and soluble ligand (TNF-α) and receptors (TNFRs); however, little is known about how these proteins are
Natalie M. Niessen, Peter G. Gibson, Jodie L. Simpson, Hayley A. Scott, Katherine J. Baines, Michael Fricker   +5 more
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Luteolin alleviated neutrophilic asthma by inhibiting IL-36γ secretion-mediated MAPK pathways [PDF]

Pharmaceutical Biology, 2023
Context Luteolin can affect multiple biological functions, such as anti-inflammatory, antioxidant and immune enhancement processes. Luteolin can inhibit inflammation of T2-high asthma, but its role in neutrophilic asthma has been insufficently studied ...
Xin-rui Qiao, Tao Feng, Dong Zhang, Li-li Zhi, Jin-tao Zhang, Xiao-fei Liu, Yun Pan, Jia-wei Xu, Wen-Jing Cui, Liang Dong   +9 more
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The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma [PDF]

Respiratory Research, 2020
Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant, with higher hospitalization and mortality rates, which seriously affect the lives of asthmatic patients.
Jing Zhang, Zhenxing Zhu, Xu Zuo, He Pan, Yinuo Gu, Yuze Yuan, Guoqiang Wang, Shiji Wang, Ruipeng Zheng, Zhongmin Liu, Fang Wang, Jingtong Zheng   +11 more
doaj   +2 more sources

The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis [PDF]

Respiratory Research
Background Neutrophilic asthma, characterized by the relative accumulation of neutrophils in the airways, constitutes a distinct endotype of asthma resistant to corticosteroid and associated with severe and uncontrolled cases. Milk fat globule-EGF factor
Shanshan Wang, Tang Kun, Zhen Tian, Mengqi Huang, Yan Fan, Boyu Li, Hongyan Zheng, Rongman Xu, Meijia Wang, Jianping Zhao, Jungang Xie   +10 more
doaj   +2 more sources

Catalase-encapsulated matrix metalloproteinase-9 responsive nanogels for modulation of inflammatory response and treatment of neutrophilic asthma [PDF]

Journal of Nanobiotechnology
Asthma is a chronic disease with typical pathological features such as airflow limitation, airway inflammation and remodeling. Of these, neutrophilic asthma is considered to be the more severe and corticosteroid-resistant subtype of asthma.
Xiaoping Guo, Xu Zuo, Wenxue Zheng, Dan Zhao, Chao Dong, Zheng Zou, Yuanyuan Shen, Caina Xu, Chaoliang He, Fang Wang   +9 more
doaj   +2 more sources

Allergens abrogate antiinflammatory DNA effects and unmask macrophage-driven neutrophilic asthma via ILC2/STING/TNF-α signaling [PDF]

The Journal of Clinical Investigation
The mechanisms of neutrophilic and mixed neutrophilic-eosinophilic asthma are poorly understood. We found that extracellular DNA and nucleosomes (Nucs) were elevated in the airways of patients with neutrophilic-eosinophilic asthma and correlated with ...
Anand Sripada, Divya Verma, Rangati Varma, Kapil Sirohi, Carolyn Kwiat, Mohini Pathria, Mukesh Verma, Anita Sahu, Vamsi Guntur, Laurie Manka, Brian Vestal, Camille Moore, Richard J. Martin, Magdalena M. Gorska, John Cambier, Andrew Getahun, Rafeul Alam   +16 more
doaj   +2 more sources