Results 111 to 120 of about 24,238 (217)
European Journal of Immunology, Volume 56, Issue 4, April 2026.Inhaled pretreatment of mouse lungs with immunomodulatory Pam2ODN results in lung epithelial cell epigenetic reprogramming that is associated with attenuation of house dust mite extract (HDM)‐induced cDC2s and moDCs expansion in the lung, causing tolerance against HDM sensitization and restricting Th2‐cell‐induced airway eosinophilic allergic ...
Mbaya Ntita +7 more
wiley +1 more source
Development of Anti‐Inflammatory Extracellular Vesicles by Surface Expression of Syndecan‐4
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.ABSTRACT The biological functions of extracellular vesicles (EVs) depend on their cellular source. Further, different subpopulations of EVs from the same cells carry different cargo, but differences in their biological functions are less understood. We here identify a very small EV subpopulation released by HEK293F cells (miniEVs).
Lijuan Yu +4 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 7, 15 April 2026.Metabolic and nutritional stressors are a growing global health concern. This review discusses how obesity, lipids, and lipid derivatives influence lung development, homeostasis, and chronic lung disease progression, highlighting roles of alveolar surfactant and sphingolipids.
Jaco Selle +8 more
wiley +1 more source
Mediators of Inflammation, 2014 We demonstrate that high mobility group box 1 protein (HMGB1) directs Th17 skewing by regulating dendritic cell (DC) function. First, our in vitro studies reveal that recombinant HMGB1 (rHMGB1) activates myeloid DCs to produce IL-23 in vitro, and rHMGB1 ...
Fang Zhang +7 more
doaj +1 more source
Protective Role for Itaconate During Inhaled Allergen Challenge
Allergy, Volume 81, Issue 4, Page 1099-1110, April 2026.Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers +16 more
wiley +1 more source
Canadian Respiratory Journal, 2012 The present case series describes four patients with asthma, airway hyper-responsiveness and neutrophilic bronchitis who harboured abnormal cystic fibrosis transmembrance conductance regulator (CFTR) gene mutations.
Jodi Goodwin +4 more
doaj +1 more source
A Role for Non‐Canonical Caspases in Fungal Allergic Airway Disease
Clinical &Experimental Allergy, EarlyView.
Thomas J. Williams +7 more
wiley +1 more source
Features of Bronchial Asthma in Children with Overweight and Obesity
Zdorovʹe Rebenka, 2015 The article deals with the problem of comorbidity of bronchial asthma in children with overweight and obesity. The basic pathogenetic mechanisms of correlation between bronchial asthma and overweight and obesity are described.
О.P. Volosovets +3 more
doaj +1 more source
Nrf2 Deficiency Accelerates IL-17-Dependent Neutrophilic Airway Inflammation in Asthmatic Mice
AntioxidantsAsthma is a heterogeneous disease that can be broadly classified into type 2, which is primarily steroid-sensitive and eosinophilic, and non-type 2, which is primarily steroid-resistant and neutrophilic. While the mechanisms leading to the development of
Kenya Kuramoto +13 more
doaj +1 more source
Journal of investigational allergology & clinical immunology, 2009 Although eosinophilic airway inflammation is recognized as an important feature of some patients with chronic, stable asthma, evidence supports an important role for neutrophils in asthma. Neutrophils are the first cells recruited to the site of the allergic reaction.
openaire +1 more source