Results 171 to 180 of about 24,238 (217)
Some of the next articles are maybe not open access.
Neutrophilic Inflammation in Severe Asthma
International Archives of Allergy and Immunology, 2012Neutrophils may play an important role in the pathogenesis of severe asthma. Their infiltration into the airway is increased. Interleukin (IL)-8 is involved in this process, and is actually upregulated in the airways of patients. We have observed that in the absence of eosinophil chemoattractants, neutrophils stimulated by IL-8 augment eosinophil trans-
Kazuyuki, Nakagome +2 more
openaire +2 more sources
New insights in neutrophilic asthma
Current Opinion in Pulmonary Medicine, 2019Recent advances in both murine models and clinical research of neutrophilic asthma are improving our understanding on the etiology and pathophysiology of this enigmatic endotype of asthma. We here aim at providing an overview of our current and latest insights on the pathophysiology and treatment of neutrophilic asthma.Activation of the NLRP3 ...
Seys, Sven F. +3 more
openaire +2 more sources
P74 Raised neutrophil elastase activity in asthma supports a neutrophilic-asthma endotype
Primary care and paediatric asthma, 2021Introduction Asthma is a common, chronic lung disease marked by reversible airflow obstruction driven by inflammation. There is increasing evidence for a neutrophil-dominant inflammatory endotype1 with clear mechanistic potential for neutrophil elastase (NE) to cause clinical manifestations of disease.
H Crisford +5 more
openaire +1 more source
Therapeutic implications of ‘neutrophilic asthma’
Current Opinion in Pulmonary Medicine, 2015This review examines the association between airway neutrophilia and severe asthma, potential mechanisms, and the effect on asthma control of therapies directed at reducing airway neutrophil numbers or activity.The majority of studies that observe an association between airway neutrophilia and severe asthma are cross-sectional in nature, and the ...
Parameswaran, Nair +2 more
openaire +2 more sources
Neutrophil ghosts worsen asthma
Science Immunology, 2018Neutrophil cytoplasts are linked to amplification of T helper 17–mediated inflammation and severe asthma. See related Research Article by Krishnamoorthy et al .
openaire +2 more sources
Neutrophils in asthma pathophysiology
Current Allergy and Asthma Reports, 2003Although the role of eosinophils, mast cells, and T cells in asthma has long been recognized, several reports suggest that neutrophils may also be involved. In most studies of people with mild asthma, neutrophil numbers in the airways are not different from controls.
openaire +2 more sources
Neutrophil extracellular traps and neutrophilic asthma
Respiratory MedicineThere are more than 260 million asthma patients worldwide. How to provide targeted long-term standardized treatment and management still confuses clinical workers and patients. Neutrophilic asthma is a special type of asthma which is difficult to diagnose clinically and often associated with severe asthma and glucocorticoid resistance.
Jiayi Xiang, Muyan Cui, Yuling Zhang
openaire +2 more sources
The European respiratory journal. Supplement, 1989
The importance of inflammation in asthma has been recognized for a long time and recently proved in man and animal models. All inflammatory cells are probably involved in exacerbations of asthma. Neutrophils in particular are present in the airways during and after the spontaneous asthma attacks in man and during asthmatic reactions and airway ...
Boschetto P. +3 more
openaire +3 more sources
The importance of inflammation in asthma has been recognized for a long time and recently proved in man and animal models. All inflammatory cells are probably involved in exacerbations of asthma. Neutrophils in particular are present in the airways during and after the spontaneous asthma attacks in man and during asthmatic reactions and airway ...
Boschetto P. +3 more
openaire +3 more sources
Asthma exacerbated by neutrophil ghosts
Nature Reviews Immunology, 2018Neutrophil cytoplasts promote T helper 17 cell responses that propagate neutrophilic inflammation in severe asthma.
openaire +2 more sources
Role of neutrophils in equine asthma
Animal Health Research Reviews, 2018AbstractNeutrophilic bronchiolitis is the primary lesion in asthma-affected horses. Neutrophils are key actors in host defense, migrating toward sites of inflammation and infection, where they act as early responder cells toward external insults. However, neutrophils can also mediate tissue damage in various non-infectious inflammatory processes ...
Benjamin, Uberti, Gabriel, Morán
openaire +2 more sources