Neutrophil and neutrophil extracellular trap involvement in neutrophilic asthma: A review. [PDF]
Medicine (Baltimore)Asthma is a highly prevalent chronic inflammatory disease characterized by variable airflow obstruction and airway hyperresponsiveness. Neutrophilic asthma (NA) is classified as “type 2 low” asthma, defined as 65% or more neutrophils in the total cell count.
Li Y, Yang T, Jiang B.
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Distinctive CD39+CD9+ lung interstitial macrophages suppress IL-23/Th17-mediated neutrophilic asthma by inhibiting NETosis [PDF]
Nature CommunicationsThe IL-23-Th17 axis is responsible for neutrophilic inflammation in various inflammatory diseases. Here, we discover a potential pathway to inhibit neutrophilic asthma.
Seunghan Han +21 more
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Nociceptor neurons control pollution-mediated neutrophilic asthma. [PDF]
ElifeAbstract The immune and sensory nervous systems, having evolved together, use a shared language of receptors and transmitters to maintain homeostasis by responding to external and internal disruptions. Although beneficial in many cases, neurons can exacerbate inflammation during allergic reactions, such as asthma.
Wang JC +8 more
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Relationship between Th17-mediated immunity and airway inflammation in childhood neutrophilic asthma [PDF]
Allergy, Asthma & Clinical Immunology, 2021 Background The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis of neutrophilic asthma in human is still under investigation.
Qing Wei +5 more
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Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s [PDF]
The Journal of Clinical InvestigationGroup 3 innate lymphoid cells (ILC3s) have emerged as an important player in the pathogenesis of neutrophilic asthma. However, the regulatory mechanism supporting ILC3 responses in the lung remains largely unclear.
Jheng-Syuan Shao +6 more
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Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputumResearch in context [PDF]
EBioMedicineSummary: Background: Eosinophilic and neutrophilic asthma defined by high levels of blood and sputum eosinophils and neutrophils exemplifies the inflammatory heterogeneity of asthma, particularly severe asthma.
Khezia Asamoah +9 more
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MARCKS protein is a potential target in a naturally occurring equine model of neutrophilic asthma [PDF]
Respiratory ResearchBackground Asthma is a chronic inflammatory airway disease that affects millions of people worldwide. Horses develop asthma spontaneously and serve as a relevant model for multiple phenotypes and endotypes of human asthma.
Haleigh E. Conley +4 more
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Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma [PDF]
Respiratory Research, 2021 Background Patients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases, transmembrane protease serine 2 (TMPRSS2) and FURIN, are needed for viral attachment and ...
Nazanin Zounemat Kermani +13 more
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Frontiers in Microbiology, 2023 BackgroundNeutrophilic asthma is poorly responsive to corticosteroids, and the mechanism underlying its pathogenesis remains unclear. Non-typeable Haemophilus influenzae (NTHi) is the most common bacterium found in induced sputum from patients with ...
Ying Zhang +4 more
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PLoS ONE, 2021 Asthma is a heterogeneous disease with neutrophilic and eosinophilic asthma as the main endotypes that are distinguished according to the cells recruited to the airways and the related pathology.
Müge Özkan +2 more
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