Results 31 to 40 of about 24,238 (217)
Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]
, 2005 This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Gibson, Anthony +9 more
core +1 more source
Neutrophilic Inflammation in Severe Persistent Asthma [PDF]
American Journal of Respiratory and Critical Care Medicine, 1999 Airway inflammation in severe asthma is not well characterized but may involve neutrophils. We have compared induced sputum profiles in patients with asthma of varying severity and normal control subjects. We have also measured exhaled nitric oxide (NO) as a noninvasive marker of inflammation.
Jatakanon A +5 more
openaire +3 more sources
Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease. [PDF]
PLoS Pathogens, 2011 A subset of patients with stable asthma has prominent neutrophilic and reduced eosinophilic inflammation, which is associated with attenuated airways hyper-responsiveness (AHR).
Ama-Tawiah Essilfie +7 more
doaj +1 more source
T2-Low Asthma: A Discussed but Still Orphan Disease
Biomedicines, 2023 Asthma affects 10% of the worldwide population; about 5% of cases are severe with the need for target therapies such as biologics. All the biologics approved for asthma hit the T2 pathway of inflammation.
Francesca Peri +5 more
doaj +1 more source
Respiratory Research, 2020 Background Neutrophilic subtype asthma occurs in approximately 15–25% of the asthma cases and is associated with severe airflow obstruction, corticosteroid resistance.
Wenjuan Xu +3 more
doaj +1 more source
Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection [PDF]
, 2015 Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated.
Snelgrove, RJ
core +1 more source
Neutrophilic asthma: welcome back! [PDF]
European Respiratory Journal, 2019 Bullone and co-workers show that neutrophilic asthma is a subtype in which the IL-17 pathway seems to be operational. It can be recognised by quantitative immunostaining of bronchial biopsy specimens and may be amenable to specific targeted therapies.http://bit.ly ...
Peter G. Gibson, Paul S. Foster
openaire +2 more sources
Microbial ligand costimulation drives neutrophilic steroid-refractory asthma [PDF]
, 2015 Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found in allergens.
Brombacher, Frank +16 more
core +7 more sources
Bioactive Materials, 2023 Asthma is a serious global public health concern. Airway neutrophilic inflammation is closely related to severe asthma, for which effective and safe therapies remain to be developed.
Jiajun Cai +9 more
doaj +1 more source
The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? [PDF]
, 2017 Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR.
Adams +6 more
core +2 more sources