Dexamethasone and RU24858 induce survival and growth factor receptor bound protein 2, leukotriene B4 receptor 1 and annexin-1 expression in primary human neutrophils [PDF]
, 2012 Glucocorticoids are widely used anti-inflammatory medication in diseases like asthma and chronic obstructive pulmonary disease. Glucocorticoids can either activate (transactivation) or inhibit (transrepression) transcription. RU24858 was introduced as a
Adcock, I +4 more
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Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation
Frontiers in Immunology, 2022 Asthma is phenotypically heterogeneous with several distinctive pathological mechanistic pathways. Previous studies indicate that neutrophilic asthma has a poor response to standard asthma treatments comprising inhaled corticosteroids.
Ji Young Kim +12 more
doaj +1 more source
, 1998 Acneiform dermatoses are follicular eruptions. The initial lesion is inflammatory, usually a papule or pustule. Comedones are later secondary lesions, a sequel to encapsulation and healing of the primary abscess.
Jansen, Thomas, Plewig, G.
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Different regulation of cigarette smoke induced inflammation in upper versus lower airways [PDF]
, 2010 Background: Cigarette smoke (CS) is known to initiate a cascade of mediator release and accumulation of immune and inflammatory cells in the lower airways.
Huvenne, Wouter +11 more
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Inflammasomes in COPD and neutrophilic asthma [PDF]
Thorax, 2015 Inflammasomes have recently been identified to be critical and potent inducers of inflammation that when overactive may be targeted therapeutically in inflammatory diseases. Inflammasomes are multiprotein signalling complexes that control the maturation and release of pro-inflammatory cytokines in response to numerous exogenous, endogenous and ...
Kim. Richard Y. +5 more
openaire +3 more sources
Neutrophilic inflammation in childhood bronchial asthma [PDF]
Thorax, 2005 Although there is increasing evidence that neutrophilic inflammation is involved in enhanced bronchial reactivity and exacerbation of bronchial asthma,1,2 the definitive role of neutrophil mediated inflammation in the pathophysiology has not been fully established.
K, Yasui +6 more
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Precision Medicine in Targeted Therapies for Severe Asthma:Is There Any Place for "omics" Technology? [PDF]
, 2018 According to the current guidelines, severe asthma still represents a controversial topic in terms of definition and management. The introduction of novel biological therapies as a treatment option for severe asthmatic patients paved the way to a ...
Bertolini, Francesca +6 more
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Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury. [PDF]
, 2018 BACKGROUND: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2.
core +2 more sources
Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma
Mediators of Inflammation, 2015 Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic inflammatory patterns. Eosinophilic inflammation can be associated with the
Girolamo Pelaia +6 more
doaj +1 more source
Canadian Respiratory Journal, 2021 Background. Quinoline-3-carboxamides have been used to treat autoimmune/inflammatory diseases in humans because they inhibit the functions of S100 calcium-binding protein A9 (S100A9), which participates in the development of neutrophilic inflammation in ...
Jong-Uk Lee +8 more
doaj +1 more source