Results 171 to 180 of about 534,504 (310)

Nucleotide signaling in neutrophils: a key player in cancer dynamics. [PDF]

Purinergic Signal
da Silva JLG, Sévigny J, Leal DBR.
europepmc   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Neutrophil-mediated inflammation linking cigarette smoke exposure to rheumatoid arthritis pathogenesis

Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by joint inflammation and progressive destruction, often preceded by the appearance of anti-citrullinated protein antibodies (ACPA).
Maisha, Jeba Atkia
core  

Optic atrophy 1 (OPA1) is essential for NET formation and antibacterial functions in neutrophils

, 2016
The precise nature of anti-bacterial and anti-fungal inflammatory responses has not yet been completely defined. Besides intracellular killing, neutrophils are able to exert an antibacterial effect in the extracellular space by forming so-called ...
Amini, Poorya
core  

Identification of immunosuppressive neutrophils using multi-omics: why functional testing remains key. [PDF]

Front Immunol
van Oosterom F, Gankema AAF, Rojas-Rodriguez F, Hoogendijk AJ, Kuijpers TW.   +4 more
europepmc   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Preferential recruitment of neutrophils by endothelin-1 in acute lung inflammation induced by lipopolysaccharide or cigarette smoke

, 2008
Tapan Bhavsar, Xing Jian Liu, Hardik Patel, Ralph Stephani, Jerome O CantorSt John’s University, School of Pharmacy and Allied Health Sciences, New York, USAAbstract: This study examined the role of endothelin-1 (ET-1) in recruiting ...
Jerome O Cantor, Hardik Patel, Xing Jian Liu, Tapan Bhavsar, Ralph Stephani   +4 more
core  

The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy. [PDF]

MedComm (2020)
Ma Z, Wang Q, Zhang Y, Li Y, Wu H, Yang H, Li X.   +6 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Sex-dependent transcriptional and epigenetic regulation of neutrophil inflammatory programs in COPD. [PDF]

Front Immunol
Mariotti B, Gasperini S, Bracaglia C, Frigenti C, Sartori G, di Chiara C, Sangiovanni F, Crisafulli E, Bazzoni F.   +8 more
europepmc   +1 more source