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Immunity, 2021
Neutrophils are immune cells with unusual biological features that furnish potent antimicrobial properties. These cells phagocytose and subsequently kill prokaryotic and eukaryotic organisms very efficiently. Importantly, it is not only their ability to attack microbes within a constrained intracellular compartment that endows neutrophils with ...
Garth Lawrence Burn +4 more
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Neutrophils are immune cells with unusual biological features that furnish potent antimicrobial properties. These cells phagocytose and subsequently kill prokaryotic and eukaryotic organisms very efficiently. Importantly, it is not only their ability to attack microbes within a constrained intracellular compartment that endows neutrophils with ...
Garth Lawrence Burn +4 more
openaire +3 more sources
Nature Reviews Immunology, 2019 Structured models of ontogenic, phenotypic and functional diversity have been instrumental for a renewed understanding of the biology of immune cells, such as macrophages and lymphoid cells. However, there are no established models that can be used to define the diversity of neutrophils, the most abundant myeloid cells.
Andres Hidalgo +2 more
exaly +4 more sources
Current Opinion in Immunology, 1989
In 'beneficial inflammation', which is the major component of our innate immune system, it is possible to predict an 'ideal' sequence of cellular events: neutrophil migration would be rapid; time of contact with endothelial cells minimized; matrix degradation localized, with specific turn-on and turn-off of degradation mechanisms; neutrophil secretion ...
C, Haslett, J S, Savill, L, Meagher
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In 'beneficial inflammation', which is the major component of our innate immune system, it is possible to predict an 'ideal' sequence of cellular events: neutrophil migration would be rapid; time of contact with endothelial cells minimized; matrix degradation localized, with specific turn-on and turn-off of degradation mechanisms; neutrophil secretion ...
C, Haslett, J S, Savill, L, Meagher
openaire +2 more sources
Neutrophil chemotactic activity of rabbit neutrophils
Archives of Oral Biology, 1974Abstract Neutrophils regularly migrate into crevices of both healthy and inflamed gingiva. In the presence of inflamed gingiva, dental plaque supplies substances with a chemotactic effect on neutrophils. but the substances responsible for the attraction of neutrophils to crevices of healthy gingiva have not been identified.
G, Tynelius-Bratthall, J, Lindhe
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Nature Immunology, 2014 In this Review we discuss data demonstrating recently recognized aspects of neutrophil homeostasis in the steady state, granulopoiesis in 'emergency' conditions and interactions of neutrophils with the adaptive immune system. We explore in vivo observations of the recruitment of neutrophils from blood to tissues in models of blood-borne infections ...
William Nauseef
exaly +4 more sources
Current Allergy and Asthma Reports, 2007
Asthma is a complex disease with a significant inflammatory component. Multiple cell types are involved in its pathophysiology. The presence of eosinophils, the cell usually associated with allergic diseases, does not fully explain the inflammation found in asthma.
Ana L, Macdowell, Stephen P, Peters
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Asthma is a complex disease with a significant inflammatory component. Multiple cell types are involved in its pathophysiology. The presence of eosinophils, the cell usually associated with allergic diseases, does not fully explain the inflammation found in asthma.
Ana L, Macdowell, Stephen P, Peters
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Neutrophil extracellular traps and neutrophilic asthma
Respiratory MedicineThere are more than 260 million asthma patients worldwide. How to provide targeted long-term standardized treatment and management still confuses clinical workers and patients. Neutrophilic asthma is a special type of asthma which is difficult to diagnose clinically and often associated with severe asthma and glucocorticoid resistance.
Jiayi, Xiang, Muyan, Cui, Yuling, Zhang
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The Neutrophil and Preeclampsia
Seminars in Reproductive Medicine, 1998Endothelial injury is common to all pathological features of preeclampsia. Neutrophil activation has been implicated in the pathophysiology of preeclampsia and requires binding and transmigration of neutrophils through the endothelium. This occurs via an interaction of endothelial adhesion molecules and surface receptors on neutrophils. Upon activation,
P, Clark, F, Boswell, I A, Greer
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1989
The red bone marrow — the source of all blood cells — is a large, but dispersed organ, about the size of the liver. In steady state, about 7 * 1010 mature neutrophilic granulocytes (hereafter called PMN-“polymorphonuclears” — or just granulocytes) – are mobilized daily from red bone marrow to blood.
H B, Benestad, O D, Laerum
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The red bone marrow — the source of all blood cells — is a large, but dispersed organ, about the size of the liver. In steady state, about 7 * 1010 mature neutrophilic granulocytes (hereafter called PMN-“polymorphonuclears” — or just granulocytes) – are mobilized daily from red bone marrow to blood.
H B, Benestad, O D, Laerum
openaire +2 more sources