Results 181 to 190 of about 761,815 (305)

Neutrophil CD14 is a driver and a therapeutic target for deep vein thrombosis. [PDF]

Blood Adv
Pandey N, Kaur H, Mitra R, Chandaluri L, Shaaban N, Martinez A, Kidder E, Anand SK, Butler ME, Zhang X, Goswami D, Frausto L, Kumar D, Pandit R, Das S, Rohilla S, Mohajan S, Male G, Huque A, Salem AR, Magdy T, Gross DS, Stokes KY, Orr AW, Tousif S, Yurdagul A, Rom O, Dhanesha N.   +27 more
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Fumarate inhibits the formation of neutrophil extracellular traps (NETs) in a Nrf2-controlled and Annexin-A1-dependent manner associated with mitochondrial fusion. [PDF]

Front Immunol
Burczyk G, Kolaczkowska E.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Increased Bacterial Load per Neutrophil Reduces Intracellular Killing Capacity. [PDF]

J Innate Immun
Duebel LV, Dekker SO, Bongers SH, van Aalst C, Mulder E, Hietbrink F, Koenderman L, Vrisekoop N.   +7 more
europepmc   +1 more source

Thermally Degradable Biocompatible Hydrogel as Transient Encapsulation Coating for Implantable Sensors

Advanced Science, EarlyView.
A biocompatible hydrogel coating with tissue‐like mechanics and reversible dissolution triggered by a mild, physiologically compatible temperature drop (≈37°C → ≈25°C) was developed for the transient encapsulation of implantable devices. The physically crosslinked methylcellulose, polyethylene glycol and polyacrilic acid (MC/PEG/PAA) hydrogel ...
Francesca Persano, Eleonora Vandini, Eleonora Daini, Antonietta Vilella, Daniela Giuliani, Leonardo Lamanna, Marco Friuli, Christian Demitri, Laura Pecoraro, Amilcare Barca, Tiziano Verri, Cosimino Malitesta, Martina Corsi, Giuseppe Barillaro, Elisabetta Mazzotta   +14 more
wiley   +1 more source

Aging changes the mechanism that underlies JAK2 modulation of neutrophil function. [PDF]

J Immunol
Feldmann JW, Kays M, McGinnis F, Herron E, Sati N, Woods C, Coulibaly AP.   +6 more
europepmc   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

COVID-19 vaccination shifts neutrophils toward a mixed activated and regulatory phenotype in patients with severe disease. [PDF]

Mol Biol Rep
de Oliveira YLM, de S Resende A, de Franca MNF, Santos CNO, Magalhães LS, Correa CB, Dos S Almeida PL, da Silva AM, Lipscomb MW, de Moura TR.   +9 more
europepmc   +1 more source

Netting neutrophils in autoimmune small-vessel vasculitis

Nature Medicine, 2009
K. Kessenbrock, M. Krumbholz, U. Schönermarck, W. Back, W. Gross, Z. Werb, H. Gröne, V. Brinkmann, D. Jenne   +8 more
semanticscholar   +1 more source