Results 231 to 240 of about 530,516 (247)

Neutrophil Plasticity in Airway Disease: Balancing Damage and Repair. [PDF]

J Innate Immun
Janciauskiene SM, Chorostowska-Wynimko J, Olejnicka B, Wrenger S.   +3 more
europepmc   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Neutrophils in Intracerebral Hemorrhage: Roles, Mechanisms, and Therapeutic Implications. [PDF]

Mediators Inflamm
Chu J, Qiu Y, Zhou Q, Yu J.
europepmc   +1 more source

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source

Granulocytes and their Involvement in the Foreign Body Response to Biomaterials and Tissue Repair. [PDF]

In Vivo
Barbeck M, Jung O.
europepmc   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

From Defense to Dysfunction: Decoding the Paradox of Emergency Granulopoiesis in Sepsis Pathogenesis. [PDF]

Research (Wash D C)
Wu X, Liu S, Hu W, Peng Q, Huang W, Ding J, Huang Y, Qiu H.   +7 more
europepmc   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Architecture of the neutrophil compartment. [PDF]

Nature
Cerezo-Wallis D, Rubio-Ponce A, Richter M, Pitino E, Kwok I, Marteletto G, Guanolema-Coba AC, Shih C, Huang RK, Moraga A, Bravo NB, Doré S, Callejas S, Aragonés DG, Jiménez-Carretero D, Martin D, Ovadia S, Vicanolo T, Crainiciuc G, Sicilia J, Deng T, Martin A, Zhang J, Cuartero MI, Giraldo DM, Garcia-Culebras A, Aroca-Crevillen A, Martín-Salamanca S, Torroja C, Ruiz M, Ruano I, Ng MSF, Hou J, Wang Y, Zhang M, Pu J, Herruzo A, van Oordt DC, Chang S, Downie AE, Chen F, Graham AL, Gause WC, Fiset PO, Spicer JD, Heyn H, Zuriaga MA, Bernal JA, Udalova IA, Moro MA, de Bock K, Dopazo A, Fuster JJ, Sánchez-Cabo F, Nieto JC, Calvo GF, Skokowa J, Soehnlein O, Quail DF, Walsh LA, Ng LG, Hidalgo A, Ballesteros I.   +62 more
europepmc   +1 more source