Results 271 to 280 of about 760,634 (335)

Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response. [PDF]

Front Immunol
Lika J, Votava JA, Datta R, Mellado Fritz CA, Kralovec AM, Smith FM, Huttenlocher A, Skala MC, Fan J.   +8 more
europepmc   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang, Yan Guo, Wen‐Jing Yuan, Yu‐Man Chen, Bo‐Wei Liu, Wen‐Tao Li, Xiang‐Ming Ding, Xu‐Dong Fu, Yu‐Han Lou, Zhuo‐Ran Chen, Xiao‐Ying Luo, Song‐Ze Ding, Bing‐Yong Zhang, Xiu‐Ling Li, Yong‐Zhi Hong, Shun‐Dong Cang, Dong‐Xiao Li, Ling Lan   +17 more
wiley   +1 more source

Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB-HIF-1α-CXCL1. [PDF]

Cell Mol Biol Lett
Wang Q, Zhang X, Han C, Lv Z, Zheng Y, Liu X, Du Z, Liu T, Xue D, Li T, Wang L.   +10 more
europepmc   +1 more source

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang   +15 more
wiley   +1 more source

Targeting mitochondrial complex I of CD177⁺ neutrophils alleviates lung ischemia-reperfusion injury. [PDF]

Cell Rep Med
Wu J, Gao P, Yang C, Zhuang F, Luo Y, Wen F, Zhang P, Wang L, Xie H, Dai C, Zhao D, Li C, Deng H, Deng Z, Chen C.   +14 more
europepmc   +1 more source

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source

Role of Neutrophils in Anti-Tumor Activity: Characteristics and Mechanisms of Action. [PDF]

Cancers (Basel)
Chen X, Chen B, Zhao H.
europepmc   +1 more source

Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma [PDF]

, 2018
Belt, Brian A, Cullinan, Darren R, DeNardo, David G, Fields, Ryan C, Gillanders, William E, Goedegebuure, Peter, Han, Booyeon J, Hawkins, William G, Jacobs, Ryan C, Linehan, David C, Nywening, Timothy M, Panni, Roheena Z, Patel, Ankit A, Sanford, Dominic E, Ye, Jian   +14 more
core   +1 more source

Accelerating Sono‐Piezoelectric Charge Transport for Antibacterial Therapy and Bone Regeneration by Metal‐Deficient TiO2 Spin‐Polarization Effect

Advanced Science, EarlyView.
The deficient TiO2 (DTO) and Barium titanate (BTO) heterojunction treats osteomyelitis through SDT. The spin‐polarization effect induced by the unpaired spin electrons in Ti atoms can expedite the transfer of ultrasonic piezoelectric charges in BTO, enhancing surface sonocatalytic efficiency.
Chaofeng Wang, Shuilin Wu, Congyang Mao, Liguo Jin, Hanpeng Liu, Yufeng Zheng, Chunyong Liang, Shengli Zhu, Zhaoyang Li, Hui Jiang, Xiangmei Liu   +10 more
wiley   +1 more source

Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia. [PDF]

PLoS Pathog
Luo Q, Shen L, Yang S, Zhang Y, Pan Y, Wu Z, Shu Q, Chen Q.   +7 more
europepmc   +1 more source