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2009
Treatment of HIV-1 infections with nevirapine is associated with skin and liver toxicity. These two organ toxicities range from mild to severe, in rare cases resulting in life-threatening liver failure or toxic epidermal necrolysis. The study of the mechanistic steps leading to nevirapine-induced skin rash has been facilitated by the discovery of an ...
M, Popovic +7 more
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Treatment of HIV-1 infections with nevirapine is associated with skin and liver toxicity. These two organ toxicities range from mild to severe, in rare cases resulting in life-threatening liver failure or toxic epidermal necrolysis. The study of the mechanistic steps leading to nevirapine-induced skin rash has been facilitated by the discovery of an ...
M, Popovic +7 more
openaire +2 more sources
International Journal of STD & AIDS, 2006
The number of HIV-infected patients who are newly exposed to nevirapine is increasing worldwide. To minimize toxicity, clinicians must adhere to dosing guidelines, avoid prescribing the drug in patients with known increased risk of toxicity, and promptly recognize toxicities, which are mainly cutaneous and hepatic.
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The number of HIV-infected patients who are newly exposed to nevirapine is increasing worldwide. To minimize toxicity, clinicians must adhere to dosing guidelines, avoid prescribing the drug in patients with known increased risk of toxicity, and promptly recognize toxicities, which are mainly cutaneous and hepatic.
openaire +2 more sources
Clinical Immunotherapeutics, 1996
▲ Nevirapine is a potent noncompetitive inhibitor of the retroviral enzyme reverse transcriptase, which is necessary for HIV replication. The agent selectively inhibits HIV-1 but not HIV-2, and it is >8000-fold more selective for infected than uninfected cells.
Sanjay S. Patel, Paul Benfield
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▲ Nevirapine is a potent noncompetitive inhibitor of the retroviral enzyme reverse transcriptase, which is necessary for HIV replication. The agent selectively inhibits HIV-1 but not HIV-2, and it is >8000-fold more selective for infected than uninfected cells.
Sanjay S. Patel, Paul Benfield
openaire +1 more source