Results 91 to 100 of about 49,279 (304)

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

Nature Communications, 2018
Melanocytic nevus count is associated with melanoma risk. In this study, a meta-analysis of 11 nevus GWAS studies identifies novel SNPs in KITLG and 9q32, and bivariate analysis with melanoma GWAS meta-analysis reveals that most nevus genes affect ...
David L. Duffy, Gu Zhu, Xin Li, Marianna Sanna, Mark M. Iles, Leonie C. Jacobs, David M. Evans, Seyhan Yazar, Jonathan Beesley, Matthew H. Law, Peter Kraft, Alessia Visconti, John C. Taylor, Fan Liu, Margaret J. Wright, Anjali K. Henders, Lisa Bowdler, Dan Glass, M. Arfan Ikram, André G. Uitterlinden, Pamela A. Madden, Andrew C. Heath, Elliot C. Nelson, Adele C. Green, Stephen Chanock, Jennifer H. Barrett, Matthew A. Brown, Nicholas K. Hayward, Stuart MacGregor, Richard A. Sturm, Alex W. Hewitt, Melanoma GWAS Consortium, Manfred Kayser, David J. Hunter, Julia A. Newton Bishop, Timothy D. Spector, Grant W. Montgomery, David A. Mackey, George Davey Smith, Tamar E. Nijsten, D. Timothy Bishop, Veronique Bataille, Mario Falchi, Jiali Han, Nicholas G. Martin   +44 more
doaj   +1 more source

Population Pharmacokinetics and Exposure‐Response Relationship of Hemoporfin in Pediatric Patients With Port‐Wine Stain

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Hemoporfin, a porphyrin derivative photosensitizer, has been approved for the treatment of port‐wine stain (PWS) in adults. However, its optimal dose for the pediatric population remains unclear. This study aimed to explore appropriate dosing for pediatric patients with PWS through population pharmacokinetics (PopPK) and exposure‐response (ER)
Rong Chen, Bin Zhang, Jining Tao, Qingyu Yao, Tianyan Zhou, Lin Ma, Zigang Xu   +6 more
wiley   +1 more source

Morphologic characteristics of nevi associated with melanoma: a clinical, dermatoscopic and histopathologic analysis

Dermatology Practical & Conceptual, 2018
Background: The aim of this retrospective study was to determine the frequency of nevus-associated melanomas and to better characterize the preexisting nevus from a histopathologic, clinical and dermatoscopic point of view.
Temeida Alendar, Harald Kittler
doaj  

Poliosis overlying a nevus with blue nevus features

Dermatology Online Journal, 2008
Poliosis is a localized patch of gray or white hair. Because it can be seen with a variety of disorders and drugs, a full history and exam is indicated. Additionally, it can be associated with underlying benign and malignant tumors, necessitating histological identification. We review the lesions that are reported with poliosis.
Young, Lorraine C, Dyke, Gregory S Van, Lipton, Shira, Binder, Scott W   +3 more
openaire   +5 more sources

Congenital triangular alopecia associated with phakomatosis pigmentovascularis type ii along with Klippel Trenaunay syndrome

Indian Dermatology Online Journal, 2020
Phakomatosis pigmentovascularis (PPV) is characterized by the association of a vascular nevus with a pigmentary nevus and is divided into five subtypes.
Aastha Gupta, Ananta Khurana, Purnima Malhotra, Kabir Sardana   +3 more
doaj   +1 more source

Large Congenital Melanocytic Nevus With LMNA::NTRK1 Fusion: Expanding Targeted Therapy Options for Congenital Nevi and Melanoma. [PDF]

J Cutan Pathol
ABSTRACT Large congenital melanocytic nevi/nevus (LCMN) are caused by genetic events that activate the mitogen‐activated protein kinase (MAPK) and extracellular signal‐regulated kinase (ERK) pathway. Individuals with LCMN are prone to developing aggressive melanomas during childhood.
Nagarkar A, Turbeville J, Hinshaw MA, LeBoit PE, Gagan J, Raffeld M, Aldape K, Shah N, Barr FG, Xi L, Lee I, Ferrone CK, Pack SD, Kaplan R, Malone MFW, Yohe M, Sargen MR.   +16 more
europepmc   +2 more sources

Gorlin syndrome in a patient with skin type VI [PDF]

, 2019
Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant disorder that is characterized by multiple basal cell carcinomas developing at a young age, keratocystic odontogenic tumors of the jaw, palmar or plantar ...
Anderson, Kathryn L, Difato, Thomas C, Poladian, Katlin, Taylor, Sarah L   +3 more
core  

NEVIGRAV Study: A Case–Control Analysis on Changes in Melanocytic Nevi During Pregnancy

The Journal of Dermatology, EarlyView.
ABSTRACT Pregnancy can influence modifications and appearance of melanocytic nevi, but studies report inconsistent findings, often lacking standardized methods and comparison groups. This study evaluates dermoscopic changes in nevi and the development of new melanocytic lesions in pregnant women using full‐body photography and digital dermoscopy ...
Vincenzo Maione, Anna Venturuzzo, Stefano Bighetti, Carola Romanó, Zeno Fratton, Enzo Errichetti, Marina Venturini, Luca Bettolini   +7 more
wiley   +1 more source

Infrared imaging spectroscopy of skin cancer lesions [PDF]

, 2016
Skin cancer is a disease of the twenty-first century since, unfortunately, being tan is associated to be healthy and good looking. UV radiation produces one of the most aggressive kinds of skin cancer: melanoma; once the damage is done there is no other ...
Rey Barroso, Laura
core   +1 more source

Efficacy and Safety of the Topical Gene Therapy Beremagene Geperpavec‐svdt (B‐VEC) in an Open‐Label Study of Japanese Subjects With Dystrophic Epidermolysis Bullosa

The Journal of Dermatology, EarlyView.
ABSTRACT Dystrophic epidermolysis bullosa (DEB) patients have pathogenic variants in COL7A1, leading to skin fragility, blistering, and scarring. Beremagene geperpavec‐svdt (B‐VEC) is a replication‐defective herpes simplex virus type 1 (HSV‐1)‐based gene therapy vector administered topically to deliver functional COL7A1 to DEB wounds.
Ken Natsuga, Daisuke Tsuruta, Shota Takashima, Chiharu Tateishi, Masaaki Takatoku, Brittani Agostini, Sarrah Mailliard, Nicholas J. Reitze, Rebecca T. Beacham, Alexia M. Cardiges, Michael J. Johnston, Ramakrishna Edukulla, Suma M. Krishnan   +12 more
wiley   +1 more source