Results 61 to 70 of about 34,930 (196)

Use of Ultraviolet‐Induced Fluorescence Dermoscopy for the Diagnosis of Vitiligo‐Like Lesions in Patients Receiving Immune Checkpoint Inhibitors Therapy for Advanced Melanoma: Letter to the Editor

JEADV Clinical Practice, EarlyView.
Laura Rackauskaite, Diana C. O. Jimenez, Iris Zalaudek   +2 more
wiley   +1 more source

The Prognostic Significance of Tumoral Melanosis

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Tumoral melanosis (TM) is a histological term to describe a nodular aggregation of macrophages containing melanin pigment (melanophages) that is devoid of viable melanocytes. It is most often identified in skin, where it may be appreciated clinically as a pigmented lesion; however, it can also be found in other organs such as lymph ...
Alison J. Potter, Peter M. Ferguson, Serigne N. Lo, Tasnia Ahmed, Robert V. Rawson, John F. Thompson, Georgina V. Long, Richard A. Scolyer   +7 more
wiley   +1 more source

The Pseudoinflammatory Pattern Revisited

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT In 1973, Dr. Martin C. Mihm, Jr. presented the finding that congenital melanocytic nevi, when viewed at low magnification, resemble superficial and deep perivascular dermatitis, forming the so‐called “pseudoinflammatory” pattern. One year earlier, Dr. Richard A.
Christopher R. Shea
wiley   +1 more source

Hairy Leukoplakia [PDF]

, 2017
Oral hairy leukoplakia (OHL) is a disease of the mucosa first described in 1984. This pathology is associated with Epstein-Barr virus (EBV) and occurs mostly in people with HIV infection, both immunocompromised and immunocompetent, and can affect ...
Agarwala, Sanjiv S., Burgess, Jeff, Cade, James E., Lynch, Denis P, Stafford, Gary L, Vinson, Richard P.   +5 more
core   +1 more source

Melanoma Diagnosis in the Mihm Era—And Beyond

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT During the illustrious career of Martin C. Mihm Jr., MD, the diagnosis of melanoma underwent significant changes, to which he made many contributions. In early descriptions, melanomas were fungating tumor masses that were obviously malignant, and highly lethal. In seminal work by Dr. Mihm and his mentor, Wallace H.
David E. Elder
wiley   +1 more source

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO‐C). WHO‐C presents a dichotomous classification (high‐grade versus low‐grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement.
Christopher R. Shea, Victor G. Prieto, Catherine M. Shachaf, Scott R. Florell   +3 more
wiley   +1 more source

Large Congenital Melanocytic Nevus With LMNA::NTRK1 Fusion: Expanding Targeted Therapy Options for Congenital Nevi and Melanoma

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Large congenital melanocytic nevi/nevus (LCMN) are caused by genetic events that activate the mitogen‐activated protein kinase (MAPK) and extracellular signal‐regulated kinase (ERK) pathway. Individuals with LCMN are prone to developing aggressive melanomas during childhood.
Akanksha Nagarkar, Jackson Turbeville, Molly A. Hinshaw, Philip E. LeBoit, Jeffrey Gagan, Mark Raffeld, Kenneth Aldape, Niharika Shah, Frederic G. Barr, Liqiang Xi, Ina Lee, Christina K. Ferrone, Svetlana D. Pack, Rosandra Kaplan, Mary Frances Wedekind Malone, Marielle Yohe, Michael R. Sargen   +16 more
wiley   +1 more source

On Technics and Technology as a Modification of the Death Drive

Constellations, EarlyView.
Lachlan Ross
wiley   +1 more source

Novel and recurrent histopathologic patterns of mogamulizumab‐associated rash: diagnostic implications and insights for accurate diagnosis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Mogamulizumab‐associated rash (MAR) is a frequent side‐effect of a treatment with Mogamulizumab that poses diagnostic challenges. Patients and methods We reviewed our database for novel histological patterns in MAR. Results Four new histological patterns were identified: (1) A pagetoid pattern, which could be mistaken for CD8 ...
Christina Mitteldorf
wiley   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source