Results 11 to 20 of about 26,994,982 (307)
Skin Sensitization Testing Using New Approach Methodologies
ToxicsChemical regulatory authorities require skin sensitization information for a number of chemical sectors, such as cosmetics, pesticides, newly marketed chemicals, household products, and topical pharmaceuticals [...]
Judy Strickland
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New approach methodologies for drug discovery. [PDF]
CellLiu W, Pang PD, Wu CA, Tagle D, Wu JC.
europepmc +2 more sources
Frontiers in Toxicology, 2022 Physiologically based kinetic (PBK) modeling has been increasingly used since the beginning of the 21st century to support dose selection to be used in preclinical and clinical safety studies in the pharmaceutical sector.
Engi Abdelhady Algharably +6 more
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New Approach Methodologies in the safety assessment of consumer products and food [PDF]
, 2021 Voedsel en consumentenproducten, zoals cosmetica, wasmiddel, textiel en speelgoed, moeten veilig voor de mens zijn. In consumentenproducten en voedsel zitten chemische stoffen. De beoordeling of deze stoffen veilig zijn, gebeurt internationaal.
Kienhuis, A +2 more
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Biomaterials and Biosystems, 2022 Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiating event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events).
Marie P.F. Corradi +7 more
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Brown Adipose Tissue Bioenergetics: A New Methodological Approach [PDF]
Advanced Science, 2017 The rediscovery of brown adipose tissue (BAT) in humans and its capacity to oxidize fat and dissipate energy as heat has put the spotlight on its potential as a therapeutic target in the treatment of several metabolic conditions including obesity and diabetes. To date the measurement of bioenergetics parameters has required the use of cultured cells or
Calderón Domínguez, María +6 more
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New methodologies for researching news discussion on Twitter [PDF]
, 2011 Twitter has become a major instrument for the rapid dissemination and subsequent debate of news stories. It has been instrumental both in drawing attention to events as they unfolded (such as the emergency landing of a plane in New York’s Hudson River in
Burgess, Jean E., Bruns, Axel
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A Short Note on Scientific Research Methodologies [PDF]
, 2023 Scientific research methodologies are critical to the advancement of scientific knowledge and the development of new theories and concepts. Researchers use a variety of methodologies to investigate phenomena, test hypotheses, and answer research ...
Bahishti, Adam A
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Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles
Frontiers in Toxicology, 2021 Lung cancer, one of the most common and deadly forms of cancer, is in some cases associated with exposure to certain types of particles. With the rise of nanotechnology, there is concern that some engineered nanoparticles may be among such particles.
Penny Nymark +4 more
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Comments/clarifications to the publication by Xin et al. (2025)
Ecotoxicology and Environmental SafetyXin et al. (2025) try to apply New Approach Methodologies (NAMs) for hazard identification and risk assessment using DINCH (cyclohexane-1,2-dicarboxylic acid, diisononyl ester, CAS Reg No 166412-78-8) as a model substance.
R. Otter +3 more
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