Results 31 to 40 of about 26,695,458 (198)
Neurodevelopment Assessment and Monitoring System (NAMS)
, 2023 <h2>What's Changed</h2> <ul> <li>Fix CI Setup by @PSchmiedmayer in https://github.com/StanfordBDHG/NAMS/pull/23</li> <li>EEG Device Pairing by @Supereg in https://github.com/StanfordBDHG/NAMS/pull/19</li> <li ...
Bauer, Andreas +2 more
core +2 more sources
A framework for chemical safety assessment incorporating new approach methodologies within REACH [PDF]
, 2022 The long-term investment in new approach methodologies (NAMs) within the EU and other parts of the world is beginning to result in an emerging consensus of how to use information from in silico, in vitro and targeted in vivo sources to assess the safety ...
Ball, Nicholas +9 more
core +2 more sources
Cosmetics, 2021 Cosmetic products need to have a proven efficacy combined with a comprehensive toxicological assessment. Before the current Cosmetic regulation N°1223/2009, the 7th Amendment to the European Cosmetics Directive has banned animal testing for cosmetic ...
Manon Barthe +10 more
doaj +1 more source
New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians [PDF]
, 2023 Multiple in vivo test guidelines focusing on the estrogen, androgen, thyroid, and steroidogenesis pathways have been developed and validated for mammals, amphibians, or fish.
Vliet, Sara M. +27 more
core +1 more source
NEW APPROACH METHODOLOGIES (NAMS) TO STUDY AGING [PDF]
Innov AgingAbstract New Approach Methodologies (NAMs) include human-relevant cell-based (in vitro), cell-free (in chemico), and computational-based (in silico) models that are complementary, not a replacement, to existing animal models. This workshop focuses on 3-dimentional (3-D) in vitro human models including tissue chips, organoids, explants ...
Cogliati, Tiziana, Fox, Jennifer
europepmc +2 more sources
EU's next generation risk assessment: hurdles and opportunities for new approach methodologies
, 2023 The EU's decision to ban animal testing for toxicity testing, has positively influenced the pace of developing New Approach Methodologies (NAMs). This development also supports replacing animal methods in other forms of risk assessment (RA), such as for ...
de Boer, A.; id_orcid +2 more
core +1 more source
Non Animal Methodologies (NAMs): research, testing, assessment and applications [PDF]
, 2019 The role of Academia to train new generation of scientists and future researchers on Non Animal Methodologies (NAMs) is crucial. Professor/student community from the Università degli Studi di Milano, Module Toxicology and in vitro models II year Master ...
Caloni F. +5 more
core +1 more source
ALTEX, 2021 The development of non-animal-based new approach methodologies (NAMs) for chemical risk assessment and safety evaluation is urgently needed. The aim of the present study was to investigate the applicability of an in vitro-in silico approach to predict human cardiotoxicity of the herbal alkaloid ibogaine and its metabolite noribogaine, which are ...
Shi, Miaoying +3 more
openaire +3 more sources
Advancing Regulatory Adoption of New Approach Methodologies. [PDF]
Clin Pharmacol TherThe U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER) has a long history advancing new approach methodologies (NAMs). In collaboration with external organizations and other regulatory agencies, FDA supports continued development of NAMs for regulatory use.
Florian J +7 more
europepmc +2 more sources
Modernizing Medical Research to Benefit People and Animals
Animals, 2022 In the context of widespread public and political concern around the use of animals in research, we sought to examine the scientific, ethical and economic arguments around the replacement of animals with New Approach Methodologies (NAMs) and to situate ...
Isobel Hutchinson +2 more
doaj +1 more source