Results 51 to 60 of about 26,695,458 (198)

Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform [PDF]

, 2022
Developmental toxicity testing urgently requires the implementation of human-relevant new approach methodologies (NAMs) that better recapitulate the peculiar nature of human physiology during pregnancy, especially the placenta and the maternal/fetal ...
Michaela Luconi, Sogorb, Miguel A., Tait, Sabrina, Markert, Udo, Luconi, Michaela, Markert, Udo R., Tobias May, Susanne Wolbank, Emilio Benfenati, Sabrina Tait, Astrid Schmidt, Marco Straccia, SOGORB, MIGUEL A, Miguel A. Sogorb, Straccia, Marco, Udo R. Markert, Schmidt, Astrid, Benfenati, Emilio, Wolbank, Susanne, Roncaglioni, Alessandra, Alessandra Roncaglioni, May, Tobias, Luconi, M   +22 more
core   +1 more source

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

Frontiers in Toxicology
As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of toxic chemicals.
Igor Snapkow, Nicola M. Smith, Emma Arnesdotter, Karsten Beekmann, Etienne B. Blanc, Albert Braeuning, Emanuela Corsini, Marija Sollner Dolenc, Loes P. M. Duivenvoorde, Gunnar Sundstøl Eriksen, Nina Franko, Valentina Galbiati, Johanna M. Gostner, Nathalie Grova, Arno C. Gutleb, Rita Hargitai, Aafke W. F. Janssen, Solveig A. Krapf, Birgitte Lindeman, Katalin Lumniczky, Ambra Maddalon, Steen Mollerup, Lucia Parráková, Arkadiusz Pierzchalski, Raymond H. H. Pieters, Raymond H. H. Pieters, Maria J. Silva, Anita Solhaug, Yvonne C. M. Staal, Anne Straumfors, Tünde Szatmári, Jonathan D. Turner, Rob J. Vandebriel, Ana Claudia Zenclussen, Robert Barouki   +34 more
doaj   +1 more source

Advancing Safety and Sustainability in Nanomaterials Industry: Methodological, Business, and Regulatory Implications

Business Strategy and the Environment, EarlyView.
ABSTRACT The rapid proliferation of chemicals and nanomaterials (CNMs) has resulted in significant cross‐sector innovation, delivering product enhancements such as improved UV protection and waterproof textiles. However, these advances present urgent challenges regarding human safety, environmental hazards, and regulatory compliance. Despite the recent
Alessandra Fiorucci, Mario Miozza, Genc Alimehmeti, Alessandra Bonoli, Angelo Paletta   +4 more
wiley   +1 more source

Disrupting Defenses: Effects of Bisphenol A and Its Analogs on Human Antibody Production In Vitro

Life
Bisphenol A (BPA) is an endocrine-disrupting chemical with estrogen-like activity, known to impair immune function. BPA may act as a pro-inflammatory agent, reducing immune response efficacy, increasing bacterial load in E.
Francesca Carlotta Passoni, Martina Iulini, Valentina Galbiati, Marina Marinovich, Emanuela Corsini   +4 more
doaj   +1 more source

The Potential for Genotoxicity, Mutagenicity and Endocrine Disruption in Triclosan and Triclocarban Assessed through a Combination of In Vitro Methods

Journal of Xenobiotics, 2023
Triclosan and Triclocarban, preservatives widely used in cosmetics and other consumer products, underwent evaluation using a battery of new-approach methodologies in vitro (NAMs).
Jan Chrz, Markéta Dvořáková, Kristina Kejlová, Danuše Očadlíková, Lada Svobodová, Lukáš Malina, Barbora Hošíková, Dagmar Jírová, Hana Bendová, Hana Kolářová   +9 more
doaj   +1 more source

The Impact of Glycation on Protein Digestibility

ChemFoodChem, EarlyView.
Schematic overview of how protein glycation affects digestibility and downstream nutritional consequences. Glycation‐derived structural modifications reduce protease accessibility, leading to limited hydrolysis and altered peptide generation. These changes decrease amino acid bioavailability and may subsequently contribute to microbiome alterations ...
Lea Hönemann, Simone Lipinski, Jana Raupbach   +2 more
wiley   +1 more source

Homophily‐adjusted social influence estimation

Canadian Journal of Statistics, EarlyView.
Abstract Homophily and social influence are two key concepts of social network analysis. Distinguishing between these phenomena is difficult, and approaches to disambiguate the two have been primarily limited to longitudinal data analyses. In this study, we provide sufficient conditions for valid estimation of social influence through cross‐sectional ...
Hanh T.D. Pham, Daniel K. Sewell
wiley   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report. [PDF]

Clin Pharmacol Ther
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Burckart GJ, Abulwerdi G, Daniels CL, Choi C, Racz R, Valentin JP, Ardlie K, Tatonetti N, Laffan S, Moreau M, Redfern W, Li L, Hickman JJ, Madabushi R, Prasad B, Yao L, Watkins PB.   +16 more
europepmc   +2 more sources

Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network

Clinical Pharmacology &Therapeutics, EarlyView.
Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang, Jashvant D Unadkat, Samuel LM Arnold, John K Fallon, Pouria Fattahi, Dan Dongeun Huh, Nicholas Ieronimakis, Edward J Kelly, Svetlana Lutsenko, Robert M Stroud, Jacqueline B Tiley, Jia Yang, Xujia Zhou, Hao Zhu, Rajini Rao, Kathleen M Giacomini, Lauren M Aleksunes   +16 more
wiley   +1 more source