Results 71 to 80 of about 26,695,458 (198)

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy

, 2019
The EU-ToxRisk research project is an interdisciplinary research project that aims to advance the paradigm shift in toxicology towards new approach methodology (NAM)–based approaches for risk assessment.
Braak, B. ter, Kamp, H., Water, B. van de, Gräpel, R., Escher, S.E., Gardner, I., Moné, M.J., Pastor, M., Kroese, D., Leist, M., Fisher, C., Ter Braak, B., Graepel, R.   +12 more
core   +1 more source

Federation of toxicological data resources for in silico new approach methodologies (NAMs)

Computational Toxicology
Next Generation Risk Assessment (NGRA) promotes animal-free, exposure-informed, and hypothesis-driven approaches to chemical safety assessment. In silico tools, such as quantitative structure-activity relationship (QSAR) models, are valuable new approach methodologies (NAMs) for use in NGRA.
Nicoleta Spînu, Dimitris Stripelis, Mark TD Cronin, Gregory L Warren, Andrew P Worth   +4 more
openaire   +1 more source

Persistence Assessment of Chemicals: Trajectories toward New Approach Methodologies (P-NAMs)

Environmental Science & Technology
Chemical persistence has long been recognized as a critical determinant of ecosystem and human exposure, exemplified by legacy pollutants such as DDT, PCBs, and, more recently, PFAS. Despite decades of regulation and research, robust experimental half-life data are available for only a fraction of chemicals in use, hampering their persistence ...
Kathrin Fenner, Daniel Zahn, Ulrich Jöhncke, Gabriel Sigmund, Philipp Mayer, Christopher Hughes, Hans Peter H. Arp, Russell J Davenport, Anu Kapanen, Thorsten Reemtsma   +9 more
openaire   +2 more sources

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source

In vitro metabolomics approaches to decipher the biochemical and cellular response to genotoxic compounds

EFSA Journal
New approach methodologies (NAMs) are gaining increasing attention within the scientific community as strategies to reduce the use of animal testing. Their integration into regulatory frameworks for chemical hazard and risk assessment in food and feed ...
Filipa Amaro, Ester Siniscalchi, Giorgia Maria Varalda, Eleonora Azzinnari, Joana Pinto, Paula Guedes dePinho, Egidio Iorio, Francesca Marcon   +7 more
doaj   +1 more source

High‐Content Screening Comparison of 1R6F Cigarette Smoke Extract and Selected Heated Tobacco and Electronic Vapour Product Aerosol Extracts in Endothelial and Bronchial Epithelial Cell Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Cigarettes induce oxidative stress and DNA damage, processes that contribute to cardiovascular and pulmonary disease. High content screening (HCS) is an increasingly valuable tool for comparative toxicology because it enables simultaneous quantification of multiple mechanistic endpoints at single‐cell resolution. In this study, HCS was used to
Edgar Trelles Sticken, Konstantinos Papikinos, Fiona Chapman, Roman Wieczorek, Sarah Jean Pour, Torge Evenburg, Sandra Otte, Tiandan Wu, Liam Simms, Matthew Stevenson   +9 more
wiley   +1 more source

Prey detection by the predator remains constant across prey densities: evidence from a field experiment in the Arctic tundra

Oikos, EarlyView.
The functional response describes how predator acquisition rates change with prey availability and integrates behavioural processes that occur during predator–prey encounters. Among these processes, prey detection represents a critical yet often overlooked component that can directly influence population dynamics. Variation in detection probability has
Matthieu Weiss‐ Blais, Andréanne Beardsell, Pierre Legagneux, Joël Bêty   +3 more
wiley   +1 more source

Using new approach methodologies (NAMs) to investigate ZnONPs and UVR induced skin sensitization

Scientific Reports
Zinc oxide nanoparticles (ZnONPs) are widely used in sunscreens and cosmetics; however, increasing evidence suggests their potential to induce skin toxicity, particularly under conditions of skin function disruption.
Yu-Ying Chen, Bour‑Jr Wang, Yung-Hsuan Cheng, Hsien-Jen Cheng, Rong‑Jane Chen, Ying-Jan Wang   +5 more
doaj   +1 more source

Towards learning and memory risk assessment with human brain organoids: barriers and opportunities

Frontiers in Toxicology
Neurodevelopmental conditions, including autism spectrum disorder, intellectual disability, and learning disabilities, as well as neurodegenerative disorders, affect millions of people in the United States alone.
Ronit Mohapatra, Dowlette-Mary Alam El Din, Hanyu Zhao, Hanyu Zhao, Thomas Hartung, Thomas Hartung, Lena Smirnova   +6 more
doaj   +1 more source