Results 91 to 100 of about 26,695,458 (198)
Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment
Drug Discovery TodaySeizures are the hallmark of treatment-resistant epilepsy and are also a frequent adverse event in drug safety testing. Here we present a critical evaluation of new approach methodologies (NAMs) in epilepsy research and seizure liability. Specifically, recent data have shown that seizure can be profiled using an in vitro seizure liability assay (iSLA ...
Ruth A. Roberts +7 more
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend New approach methodologies (NAMs) to test the pharmaco‐ and chemicokinetics of compound transfer across the human placental barrier in late pregnancy. Abstract This review addresses an important and timely topic at the intersection of placental biology with respect to barrier transfer kinetics, toxicology and mathematical ...
Paul Brownbill, Eleanor Doman
wiley +1 more source
, 2020 Skin sensitising substances which induce contact allergy and consequently risk elicitation of the disease allergic contact dermatitis (ACD) remain an important focus regarding the replacement of animal experimentation.
ROSSI Laura +31 more
core +1 more source
NAM JournalNeurodegenerative diseases are characterized by progressive neuronal loss driven not only by intrinsic cellular dysfunction but also by complex interactions within the neural microenvironment, including extracellular matrix (ECM) composition, neuroimmune
Alp Deniz Yuzbasic +3 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
BiologyAdvancing our understanding of pancreatic toxicity and metabolic disorders caused by environmental exposures requires innovative approaches. The pancreas, a vital organ for glucose regulation, is increasingly recognized as a target of harm from ...
Yue Ge
doaj +1 more source
The Plant Genome, Volume 19, Issue 4, December 2026.Abstract Complex agronomic traits in rice (Oryza sativa L.) are controlled by many genetic loci; however, dissection is often constrained in biparental mapping populations by limited recombination and narrow genetic diversity, and in diversity sets by spurious associations arising from cryptic relatedness.
Fergie Ann Quilloy +6 more
wiley +1 more source
Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?
Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1169-1172, November 2026.Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart +6 more
wiley +1 more source
New approach methodologies in human health risk assessment across European regulatory frameworks:Status quo, barriers and drivers for regulatory acceptance and use [PDF]
The traditional approaches to chemical risk assessment for human health are continuously challenged by their limitations, such as validity concerns, societal pressure to use animal-free methods, and resource constraints. New Approach Methodologies (NAMs)
Holden, Laura; id_orcid +27 more
core +1 more source
Advancing FDA New Approach Methodologies from animal models through digital twins
npj Digital MedicineIn April 2025, the U.S. Food and Drug Administration announced immediate steps toward replacing animal testing for drug evaluation with New Approach Methodologies (NAMs)—modern laboratory techniques mimicking human tissues.
Ashley L. Eadie +3 more
doaj +1 more source