Results 111 to 120 of about 26,695,458 (198)

Finding a Place for New Approach Methodologies (NAMs) in Biomedical Research

New Approach Methodologies (NAMs) can greatly contribute to the Replacement and Reduction of animal experiments in biomedical science. However, while NAMs have seen considerable investment and adoption in toxicology, this growth has not found a parallel in  basic and translational biomedical research.
Alexandra Schaffert, Arti Ahluwalia, Jeffrey Bajramovic, Nuno H. Franco, Winfried Neuhaus, I. Anna S. Olsson, Ioanna Sandvig   +6 more
openaire   +1 more source

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 21, Page 6481-6500, November 2026.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Limitations and Modifications of Skin Sensitization NAMs for Testing Inorganic Nanomaterials [PDF]

Since 2020, the REACh regulation requires toxicological data on nanoforms of materials, including the assessment of their skin-sensitizing properties.
Wareing, Britta, Kolle, Susanne N., Birk, Barbara, Aktalay Hippchen, Ayse, Landsiedel, Robert, Funk-Weyer, Dorothee   +5 more
core   +1 more source

Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics

Frontiers in Toxicology
Micro- and nanoplastics (MNPs) are widespread environmental pollutants that pose significant health risks. They originate from industrial processes, consumer products, and environmental degradation, inducing oxidative stress through cellular dysfunctions
Xian Wu, TinChung Leung, TinChung Leung, Dereje D. Jima, Dereje D. Jima, Majemite Iyangbe, John Bang, John Bang   +7 more
doaj   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, Volume 15, Issue 39, 23 October 2026.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Brain organoids are emerging as increasingly functional human‐relevant platforms, yet limitations in vascularization, maturation, measurement, and reproducibility still constrain their translational value. This Perspective examines how microfluidics, biofabrication, advanced imaging, electrophysiology, multimodal AI, standardization, and ethical ...
Aishwarya Pantula, Kaustubh Joshi, Swarangi Samant, Greta Babakhanova, Annie Kathuria   +4 more
wiley   +1 more source

Application of New Approach Methodologies to Improve Oral Biopharmaceutic Assessments

Pharmaceutics
Background/Objectives: The rapid expansion of New Approach Methodologies (NAMs) is transforming oral biopharmaceutics by offering mechanistically rich, human-relevant tools that can reduce reliance on animal testing while improving translational ...
Mauricio A. García, Miguel Ángel Cabrera-Pérez, Pablo M. González, Alexis Aceituno, Daniel Hachim   +4 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

An integrated new approach methodology for inhalation risk assessment of safe and sustainable by design nanomaterials

Environment International
The production and use of nanomaterials (NMs) has increased over the last decades posing relevant questions on their risk after release and exposure of the population or sub-populations. In this context, the safe and sustainable by design (SSbD) approach
Giulia Motta, Maurizio Gualtieri, Rossella Bengalli, Melissa Saibene, Franco Belosi, Alessia Nicosia, Joan Cabellos, Paride Mantecca   +7 more
doaj   +1 more source

Implementation of the In Vitro Seizure Liability Assay (iLAseizure) in Drug Discovery and Development: Mechanism of Action Case Studies

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Central nervous system (CNS) liabilities remain a significant cause of attrition during small molecule drug development. We previously developed the in vitro seizure liability assay (iLAseizure), a new approach methodology (NAM) comprising a human induced pluripotent stem cell neuron microelectrode array (MEA) assay coupled with a panel of ...
Kimberly Rockley, Ruth Roberts, Hannah Jennings, Karen Jones, Magali‐Anne Maizières, Michael Morton   +5 more
wiley   +1 more source