Results 121 to 130 of about 26,695,458 (198)

Applying new approach methodologies to assess next-generation tobacco and nicotine products [PDF]

In vitro toxicology research has accelerated with the use of in silico, computational approaches and human in vitro tissue systems, facilitating major improvements evaluating the safety and health risks of novel consumer products. Innovation in molecular
Damian McHugh, Liam Simms, Sara Moses, K. Monica Lee, Marianna Gaca, Hitoshi Fujimoto, David Thorne   +6 more
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DEET‐cyclodextrin inclusion complexes for mosquito and tick repellency: Extended repellency time and no zebrafish embryotoxicity

Pest Management Science, Volume 82, Issue 10, Page 9653-9665, October 2026.
Hydroxypropyl‐β‐cyclodextrin (HPβCD)–N,N‐diethyl‐meta‐toluamide (DEET) complex extended tick repellency to 168 h. Full protection against Aedes aegypti for 7 h with HPβCD‐DEET. HPβCD reduced DEET release and skin retention significantly. No embryotoxicity observed below 325 mg L−1 in zebrafish model.
Gessyka Rayana Silva Pereira, Gleidson Cardoso, Maria Luiza Kuhn Camargo, Michele Resende Machado, Mayara Macedo Barrozo, Juscelino Rodrigues, Gisele Augusto Rodrigues de Oliveira, Caio Monteiro, Christian Luz, Ricardo Neves Marreto, Stephânia Fleury Taveira   +10 more
wiley   +1 more source

Report on the European Partnership for Alternative Approaches to Animal Testing (EPAA) "New Approach Methodology (NAMs) User Forum", 30-31 October 2024, Helsinki, Finland

The European Partnership for Alternative Approaches to Animal Testing (EPAA) held the "New Approach Methodology (NAMs) User Forum" at the European Chemicals Agency, Helsinki, Finland on 30-October 31, 2024.
Cable, Sophie, Escher, Sylvia E., Maxwell, Gavin, Sobański, Tomasz, Desaintes, Christian, Fritsche, Ellen, White, Andrew J., Hessel, Ellen V.S., Kern, Petra S., Cronin, Mark T.D., Ouédraogo, Gladys D., Wehr, Matthias M.   +11 more
core   +1 more source

Developing an approach for evaluating the cardiotoxic potential of botanicals

Frontiers in Toxicology
Botanicals (e.g., extracts derived from plants, algae, or fungi) are increasingly utilized by consumers with the hope of enhancing their health, managing symptoms, or preventing ailments; however, these products have often had limited pre-market toxicity
Julie Krzykwa, Hemantkumar S. Chaudhari, Andre Monteiro Da Rocha, Matthias Gossmann, Peter Hoffmann, Yaser Khokhar, Nathan Meyer, Jin-Young K. Park, Robert Sprando, Ravi Vaidyanathan, Remco H. S. Westerink, Joseph C. Wu, Jeffrey Yourick, Shane R. Zhao, Constance A. Mitchell   +14 more
doaj   +1 more source

Menopause Literacy Gaps Across Individual, Healthcare and Societal Levels: A Qualitative Study of Women's Experiences and Healthcare Providers' Perspectives

Health Expectations, Volume 29, Issue 5, October 2026.
ABSTRACT Background Menopause is a major life transition that can affect women's physical, psychological, cognitive, sexual and social well‐being. Despite the availability of evidence‐based interventions, many women remain insufficiently informed and experience difficulties accessing reliable information and appropriate support.
Najmeh Pourshahrokhi, Jamileh Farokhzadian, Myra S. Hunter, Saeedeh Azaraeen, Leila Ahmadian   +4 more
wiley   +1 more source

Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing relevant endpoints

Frontiers in Toxicology
Differentiated primary human bronchial epithelial cell (dpHBEC) cultures grown under air-liquid interface (ALI) conditions exhibit key features of the human respiratory tract and are thus critical for respiratory research as well as efficacy and toxicity
Nicholas M. Mallek, Elizabeth M. Martin, Lisa A. Dailey, Shaun D. McCullough, Shaun D. McCullough   +4 more
doaj   +1 more source

Guidance on the data requirements for the safety assessment of bisphenols other than Bisphenol A (BPA) and their derivatives

EFSA Journal, Volume 24, Issue 10, October 2026.
Abstract Concerns regarding the safety of bisphenol A (BPA) and the resulting restrictions on its use in food contact materials (FCM) have been broadened to other ‘bisphenols and bisphenol derivatives’ (BPs). Several of these substances are considered hazardous due to their classification as carcinogenic, mutagenic, toxic to reproduction (CMR) or ...
EFSA Panel on Food Contact Materials (FCM), Claude Lambré, Riccardo Crebelli, Maria Joao Aleixo Da Silva, Konrad Grob, Ester Heath, Eugenia Lampi, Maria Rosaria Milana, Marja Pronk, Mario Ščetar, Georgios Theodoridis, Els Van Hoeck, Nadia Waegeneers, Monika Batke, Emanuela Corsini, Laetitia Lecante, Emanuela Testai, Thomas Tietz, Henk Van Loveren, Zainab Al Harraq, Eric Barthélémy, Cristina Croera, Gilles Rivière   +22 more
wiley   +1 more source

On the relevance of genomic approaches to hazard assessment of functionalized nanomaterials in the NAM framework

NAM Journal
New approach methodologies (NAMs) are changing the ways by which alternative toxicology, in vitro mainly, is approaching the evaluation of hazard of novel materials or compounds.
Giulia Motta, Barbara Torsello, Maurizio Gualtieri, Rossella Bengalli, Ilaria Zanoni, Maria Foti, Paride Mantecca   +6 more
doaj   +1 more source

CHIASMA: Advancing chemicals and materials safety and sustainability assessments through innovative integration of in vitro and in silico (new approach) methodologies

Computational and Structural Biotechnology Journal
Traditional in vivo methodologies have long formed the foundation of chemical and material safety assessment, yet they are increasingly inadequate to meet modern regulatory, ethical, and sustainability demands.
Pamina Weber, Emma Arnesdotter, Nour Attar, Steffi Friedrichs, Christian Seitz, Riju Roy Chowdhury, Katharina Koch, Tina Buerki-Thurnherr, Beatrice Brugger, Peter Wick, Jack Morikka, Angela Serra, Lorenzo Campini, Dario Greco, Valentina Lacconi, Adriana Scattareggia Marchese, Luisa Campagnolo, Thomas E. Exner, Maja Brajnik, Émilie Brun, Iseult Lynch, Dimitris Zouraris, Dimitris Mintis, Andreas Tsoumanis, Antreas Afantitis, Georgia Melagraki, Vasileios Minadakis, Paraskevi Papakyriakopoulou, Periklis Tsiros, Elisa Thépaut, Haralambos Sarimveis, Marc Majó, Roland Hischier, Ishita Virmani, Martin Paparella, Simona Kavaliauskiene, Amin Sayyari, Romain Fontaine, Mette Helen Bjørge Müller, Eunseo Lee, Zayakhuu Gerelkhuu, Tae Hyun Yoon, Duygu Turan-Sorhun, Winfried Neuhaus, Tommaso Serchi   +44 more
doaj   +1 more source

Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges

New Approach Methodologies (NAMs), broadly understood to include in silico, in chemico, in vitro and ex vivo methods, show great potential in advancing risk assessment (RA) albeit their regulatory implementation is lagging.
STANCO Deborah, OOMEN Agnes, CUBADDA Francesco, SIEWERT Katherina, VINCENTINI Olimpia, MAST Jan, LÉGER Thibaut, CHEYNS Karlien, BREMER-HOFFMANN Susanne, MCVEY Emily, SIEG Holger, FESSARD Valerie, ESCHER Sylvia E., GUTLEB Arno, LIU Yuk-Chien, HAASE Andrea, USMANI Shirin M., YU Dingyi, MONTALVO Daniela, VAN DER ZANDE Meike, RITZ Vera, SERCHI Tommaso, DUMIT Verónica I. Dumit, MERTENS Birgit, VERLEYSEN Eveline, YEO Calvin W. S. Yeo   +25 more
core   +1 more source