Results 141 to 150 of about 26,695,458 (198)

Grouping of UVCB substances with new approach methodologies (NAMs) data_suppl

ALTEX, 2020
openaire   +1 more source

Incorporating Lines of Evidence from New Approach Methodologies (NAMs) to Reduce Uncertainties in a Category Based Read-Across: A Case Study for Repeated Dose Toxicity [PDF]

A group of triazole compounds was selected to investigate the confidence that may be associated with read-across of a complex data gap: repeated dose toxicity.
Firman, JW, Cronin, MTD, Pestana, C
core  

Report on Solutions to existing Roadblocks for usage of NAMs in Regulation (Action Plan)

The goal of PrecisionTox is to advance the safety assessment of chemicals without the use of animal testing. As a first phase in the project for Work Package 6 (WP6 - Regulatory Analysis and Application), the project team undertook a comprehensive study ...
Lee, Robert; id_orcid, Holden, Laura; id_orcid, Cavoski, Aleksandra; id_orcid   +2 more
core   +1 more source

New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption - a PARC project. [PDF]

Front Toxicol
Ardenkjær-Skinnerup J, Baert Y, Bajard L, Blum J, Brion F, Coppola L, Fini JB, Fritsche E, Holbech H, Hurem S, Jacobs MN, Johansson HKL, Knapen D, Koch K, Lyche JL, Mai PNT, Neuhaus W, Nikolov NG, Nurani A, Papageorgiou K, Poulsen R, Ramhøj L, Řehůřková E, Rosenmai AK, Rüegg J, Sovadinová I, Tait S, Van de Pette M, Vanhaecke T, Vergauwen L, Wedebye EB, Xu EG, Svingen T.   +32 more
europepmc   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids. [PDF]

J Appl Toxicol
Montenegro B, Gonçalves RM, Pegurier MG, Amorim I, Rossi AM, Baptista LS.   +5 more
europepmc   +1 more source

Assessing the sensitisation hazard of microbial pesticides: potential value of New Approach Methodologies (NAMs) to overcome current challenges. [PDF]

Arch Toxicol
Leme DM, Pestana CB, Kenny EF, Feustel S, Marx-Stoelting P, Corsini E.   +5 more
europepmc   +1 more source

De-risking seizure liability: integrating adverse outcome pathways (AOPs), new approach methodologies (NAMs), and in silico approaches while highlighting knowledge gaps. [PDF]

Toxicol Sci
Behl M, Karmaus A, Rao M, Lane T, Harris J, Sachs C, Borrel A, Oyetade O, Unnikrishnan A, Hamm J, Hogberg HT.   +10 more
europepmc   +1 more source

2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives. [PDF]

Toxicol Pathol
Hogberg HT, Fritsche E, Gröters S, Kovi RC, Rao DB, Terron A, Winter MJ.   +6 more
europepmc   +1 more source

International conference and workshop on “New Approach Methodologies (NAMs) in Pharmacology and Toxicology”

ALTEX
Veni, Subramanyam, Suresh Kumar, Saravanan, Haema, Ganapthy, Raveendran, Ramaswamy, Sheikh, Raisuddin, Mohammad A, Akbarsha   +5 more
openaire   +2 more sources

Time for CHANGE : System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

There has been considerable work over the past 20 years designed to bring about a paradigm shift in regulatory toxicology from chemical risk management decisions based on data from animal studies to a “Next Generation Risk Assessments” (NGRAs) system ...
Wright, Fred, Kojima, Hajime, Ames, Heather M, Tsaioun, Katya, Krishnan, Kannan, Rousselle, Christophe, Simanainen, Ulla, Whaley, Paul, Kwon, Seok, Bloch, Denise, Vist, Gunn E, Hogberg, Helena T, Thayer, Kristina A, Bearth, Angela, Davies, Holly G, Sass, Jennifer B, Chiu, Weihsueh A, Joglekar, Rashmi, Roggen, Erwin, Hirabayashi, Yoko, Jones, Lowenna B, Husøy, Trine, Giusti, Arianna, Osborne, Olivia J, Mathisen, Gro H, Cavoski, Aleksandra, Rooney, Andrew A, Wikoff, Daniele, Hartung, Thomas, Tong, Weida, Ashikaga, Takao, Svendsen, Camilla, Sepai, Ovnair, Hoffmann, Sebastian   +33 more
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