Results 131 to 140 of about 26,695,458 (198)

New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches

Toxics
Skin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures and finished products.
Argel Islas-Robles, Meera Ramani, Jakeb Phillips, Gertrude-Emilia Costin   +3 more
doaj   +1 more source

A novel integrated testing strategy (ITS) for evaluating acute fish toxicity with new approach methodologies (NAMs)

Environment International
Acute fish toxicity (AFT) tests are performed in aquatic risk assessments of chemical compounds globally. However, the specific endpoint of in vivo AFT is based on the lethal concentration 50 (LC50), which is a serious challenge in terms of animal ...
Yen-Ling Lee, Zi-Yu Chen, Tzu-Ning Li, Jian-Feng Hsueh, Ying-Jan Wang   +4 more
doaj   +1 more source

Lessons for the Future of NAMs from History, Philosophy, and Social Studies of Science

This paper explores what we can learn from the humanities and social sciences about how standards operate in and around science, in order to understand more about how ‘the gold standard’ can be shifted away from the use of animals in research and testing,
Kirk, R., Ankeny, R., Davies, G., Johnson, J., Whittaker, A.   +4 more
core   +1 more source

Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution. [PDF]

Front Toxicol, 2023
Bouchard KV, Costin GE.
europepmc   +1 more source

Risk Characterization and Probabilistic Concentration-Response Modeling of Complex Environmental Mixtures Using New Approach Methodologies (NAMs) Data from Organotypic in Vitro Human Stem Cell Assays. [PDF]

Environ Health Perspect, 2021
Hsieh NH, Chen Z, Rusyn I, Chiu WA.
europepmc   +1 more source

Challenges in implementing new approaches methodologies (NAMs) in the risk Assessment of nanomaterials [PDF]

Manufactured nanomaterials (NMs) are increasingly used in a wide range of industrial applications leading to a constant increase in the market size of nano-enabled products. The increased production and use of NMs are constantly raising concerns among different stakeholder groups with regard to their effects on human and environmental health. Given the
Vinković Vrček, Ivana, Božičević, Lucija, Kalčec, Nikolina, Peranić, Nikolina, Celinić, Mateo   +4 more
openaire  

New approach methodologies (NAMs) for preclinical and translational evaluation of mRNA-lipid nanoparticle (LNP) therapeutics. [PDF]

J Control Release
Zhou J, Li N, Liu R, Kabanov AV, Polacheck WJ, Nguyen J, Cao Y.   +6 more
europepmc   +1 more source

Possible applications of new approach methodologies (NAMs) in ecotoxicology

ALTEX
Lorenzetti, Stefano, Amorena, Michele, Attanasio, Chiara, Calleri, Maurilio, Caloni, Francesca, Dang, ZhiChao, D'Angelo, Livia, De Angelis, Isabella, De Girolamo, Paolo, Di Cosmo, Anna, Failla, Cristina M, Ferrante, Maria C, Kuan, Michela, Libralato, Giovanni, Nevelli, Francesco, Nicolotti, Orazio, Pastorino, Paolo, Saraceni, Paolo R, Severino, Lorella, Vitale, Augusto   +19 more
openaire   +4 more sources

Editorial: European partnership on the assessment of risks from chemicals (PARC): continued focus on new approach methodologies (NAMs) and data gap filling. [PDF]

Front Toxicol
Beronius A, Roggen E, Svingen T.
europepmc   +1 more source

The rise of new approach methodologies (NAMs) for environmental safety assessment of chemicals: A systematic review of the current status, challenges and strategies for broader adoption of NAMs. [PDF]

NAM J
Christou M, Georgantzopoulou A, Hultman M, Song Y, Wennberg AC, Mentzel S, Embry M, Ott A, Suzuki T, Grassi G, Roush K, Lillicrap A.   +11 more
europepmc   +1 more source