Results 81 to 90 of about 26,695,458 (198)

Linking telemetry data with forage availability maps advances information for moose management

Wildlife Biology, EarlyView.
Evidence‐based forest and wildlife management requires precise estimates of forage availability for spatial planning and conflict mitigation. Recently, novel datasets and associated maps have been developed for use in Swedish forest and wildlife management.
Lukas Graf, Wiebke Neumann, Göran Ericsson, Annika M. Felton   +3 more
wiley   +1 more source

Hormone Replacement Therapy for Menopausal Symptoms and the Risk of Cardiometabolic Disease: Current Evidence and Future Directions

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background The transition through menopause is accompanied by a series of adverse metabolic changes which are associated with an increased risk of cardiometabolic disease, a major cause of mortality in women after midlife. Whilst the indication for menopausal hormone replacement therapy (HRT) is the control of menopausal symptoms ...
Jiawen Dong, Sarah Hillman, Sharon Dixon, Anupa Shah, Radha Venkatakrishnan, Jeremy W. Tomlinson   +5 more
wiley   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

New approach methodologies to assess wanted and unwanted drugs-induced immunostimulation

Current Research in Toxicology
This review examines various classes of drugs, focusing on their therapeutic and adverse effects, particularly in relation to immunostimulation. We emphasize the potential of new approach methodologies (NAMs) to study both expected and unexpected ...
Valeria Bettinsoli, Gloria Melzi, Irene Marchese, Sofia Pantaleoni, Francesca Carlotta Passoni, Emanuela Corsini   +5 more
doaj   +1 more source

Interaction with NEGR1 affects mGlu5 cell signalling and the neuroprotection induced by the positive allosteric modulator VU0409551

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The metabotropic glutamate receptor mGlu5 plays an important role in neuronal survival and synaptic plasticity. We and others have shown that mGlu5 positive allosteric modulators (PAMs) are biased agonists, triggering the activation of neuroprotective pathways and promoting neuronal survival. As mGlu5 biased pharmacology
Jennifer D. S. Guimaraes, Toniana G. Carvalho, Luan A. Pereira, Emanuele G. Silva, Esther M. A. Maciel, Gabriella P. Torres, Thiago Assis, Pablo L. Cardozo, Joao P. P. de Almeida, Nathalia C. Silva, Francesca Pischedda, Giovanni Piccoli, Luciene B. Vieira, Juliana Alves‐Silva, Fabiola M. Ribeiro   +14 more
wiley   +1 more source

Envisioning an international validation process for New Approach Methodologies in chemical hazard and risk assessment

, 2021
Despite the global toxicology community discussing New Approach Methodologies (NAMs) for chemical hazard and risk assessment, such as in vitro, in silico, and ‘omics-based approaches, for some 30 years, their formal adoption by regulators remains limited.
Steve Maguire, Niladri Basu, Markus Hecker, Guillaume Pain, Matthieu Mondou, Doug Crump, Gordon M. Hickey   +6 more
core   +1 more source

New ideas for non-animal approaches to predict repeated-dose systemic toxicity:report from an EPAA Blue Sky Workshop [PDF]

, 2020
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a ‘Blue Sky Workshop’ on new ideas for non-animal approaches to predict repeated-dose systemic toxicity.
Roberts, Ruth A.; id_orcid, Maurer-Stroh, S, Cull, T, Zvonimir, Z, Nordlund, Pär, Müller, Boris P., Ashton, Randolph S., Manou, I, Daston, GP, Viant, MR, Cronin, MTD, Ashton, RS, Birk, B, Mahony, Catherine, Zvonimir, Zvonar, Whelan, M, Cull, Tom, Margiotta-Casaluci, Luigi, Viant, Mark R.; id_orcid, Mahony, C, Steger-Hartmann, Thomas, Whelan, Maurice, Maurer-Stroh, Sebastian, Vinken, M, Ewart, L, Knudsen, TB, Birk, Barbara, Vinken, Mathieu, Knudsen, Thomas B., Cronin, Mark T.D., Margiotta-Casaluci, L, Vandenbossche, E, Ewart, Lorna, Boobis, Alan R., Vandenbossche, Evita, Roberts, RA, Daston, George P., Nordlund, P, Müller, BP, Steger-Hartmann, T, Boobis, AR, Manou, Irene, Catherine Mahony   +42 more
core   +1 more source

The DIKW of Transcriptomics in Ecotoxicology: Extracting Information, Knowledge, and Wisdom From Big Data

Environmental Toxicology and Chemistry, EarlyView.
Jessica A. Head, Jessica D. Ewald, Niladri Basu   +2 more
wiley   +1 more source

Advances in organic UV filters for sunscreens over the past decade

Photochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon, Maria Carolina Theisen, Andressa Motta Castro, Giovana Jones Radke, Fernando Fumagalli   +4 more
wiley   +1 more source

OECD harmonised template 201: Structuring and reporting mechanistic information to foster the integration of new approach methodologies for hazard and risk assessment of chemicals

, 2023
In the EU, the Chemical Strategy for Sustainability (CSS) highlights the need to enhance the identification and assessment of substances of concern while reducing animal testing, thus fostering the development and use of New Approach Methodologies (NAMs)
PAINI Alicia, COECKE Sandra, DAGALLIER Bertrand, RICHARDSON Jane, CARNESECCHI Edoardo, LE GOFF François, CAMPIA Ivana, LANGEZAAL Ingrid, MORATH Siegfried, MUNN Sharon, DECEUNINCK Pierre, TARAZONA Jose, WITTWEHR Clemens, DORNE Jean-Lou, LEINALA Eeva, BROWNE Patience, BATISTA LEITE Sofia   +16 more
core   +1 more source