Results 141 to 150 of about 2,993,444 (316)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
, 2021 Intrinsic or acquired resistance to chemotherapy is a major hurdle in the treatment of cancer. One of the key mechanisms of resistance is the overexpression of the drug efflux transporter P-glycoprotein (Pgp). Pgp overexpression renders a large number of
Tonissen, Kathryn, Poulsen, Sally-Ann
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A New Combination in Tabernaemontana (Apocynaceae)
Novon, 1991 In preparation of the Stemmadenia and Tabernaemontana (Apocynaceae) treatments for the upcoming Flora of the Venezuelan Guayana, the following new combination is required.
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New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol
, 2013 Mario Cazzola,1 Andrea Segreti,1 Maria Gabriella Matera2 1Department of System Medicine, University of Rome 'Tor Vergata', Rome, Italy; 2Department of Experimental Medicine, Second University, Naples, Italy Abstract: An increasing body of ...
Matera MG +3 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A New Combination in Erythrina (Leguminosae)
Novon: A Journal for Botanical Nomenclature, 2006 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
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Combination of new multifunctional molecules for erythematotelangiectatic rosacea disorder
, 2015 Hanane Chajra,1 Mahdi Nadim,2 Daniel Auriol,3 Kuno Schweikert,1 Fabrice Lefevre1 1Induchem AG, Volkestwil, Switzerland; 2CBM-CNRS, Orléans Cedex, 3Libragen SA, Toulouse, France Background: Rosacea, a common chronic skin disorder, is currently ...
Chajra H +4 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
New Combinations in Schoenoplectus (Cyperaceae)
Novon, 1993 Results from a recent taxonomic treatment of species of Scirpus sensu lato occurring in Virginia indicate that they are a heterogeneous group. 'Three segregate genera are recognized as occurring in Virginia: Scirpus sensu stricto, Trichophorum, and Schoenoplectus. The transfer of four species to Schoenloplectus is made.
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