Results 171 to 180 of about 2,993,444 (316)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Parp Inhibitors and Radiotherapy: A New Combination for Prostate Cancer (Systematic Review). [PDF]
Int J Mol Sci, 2023 Rivero Belenchón I +4 more
europepmc +1 more source
Comments on "A new combination of evidence based on compromise" by K. Yamada
, 2009 WOSComments on ``A new combination of evidence based on compromise'' by K ...
Dezert, Jean +2 more
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Gayana: Botanica, 2004 Chaetanthera acheno-hirsuta (Tombesi) Arroyo, A.M.R. Davies & Till-Bottraud (Asteraceae: Mutisieae), previously known from the upper limits of the vegetation (>3900m) on the eastern side of the Andes in San Juan Province, Argentina, is cited for Chile ...
Mary T.K. Arroyo +2 more
doaj
Yushaniatomentosa (Poaceae, Bambusoideae), a new combination from Guangxi. [PDF]
PhytoKeys, 2023 Li X, Ni JB, Tan F, Tong YH, Xia NH.
europepmc +1 more source
Forecast Combination and Bayesian Model Averaging - A Prior Sensitivity Analysis [PDF]
In this study the forecast performance of model averaged forecasts is compared to that of alternative single models. Following Eklund and Karlsson (2007) we form posterior model probabilities - the weights for the combined forecast - based on the ...
Feldkircher, Martin
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source