Results 51 to 60 of about 67,835 (263)

Grand Color axion

Journal of High Energy Physics, 2022
We present a model that solves the strong CP problem via an axion parametrically heavier than the standard one. Within this picture the Standard Model quarks are embedded into a larger non-abelian Grand Color group that at high scales splits into ...
Alessandro Valenti, Luca Vecchi, Ling-Xiao Xu   +2 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Combined constraints on dark photons and discovery prospects at the LHC and the Forward Physics Facility

Journal of High Energy Physics, 2023
Hidden sectors are ubiquitous in supergravity theories, in strings and in branes. Well motivated models such as the Stueckelberg hidden sector model could provide a candidate for dark matter.
Amin Aboubrahim, Mohammad Mahdi Altakach, Michael Klasen, Pran Nath, Zhu-Yao Wang   +4 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Baryonic dark forces in electron-beam fixed-target experiments

Journal of High Energy Physics
New GeV-scale dark forces coupling predominantly to quarks offer novel signatures that can be produced directly and searched for at high-luminosity colliders. We compute the photon-proton and electron-proton cross sections for producing a GeV-scale gauge
Safa Ben Othman, Armita Jalooli, Sean Tulin   +2 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Constraints on photon mass and dark photon from the Jovian magnetic field

Journal of High Energy Physics
The Jovian magnetic field, being the strongest and largest planetary one in the solar system, could offer us new insights into possible microscopic scale new physics, such as a non-zero mass of the Standard Model (SM) photon or a light dark photon ...
Shi Yan, Lingfeng Li, JiJi Fan
doaj   +1 more source

Constraining Vector Dark Matter with neutrino experiments

Journal of High Energy Physics, 2023
Vector Dark Matter (VDM) that couples to lepton flavor (L e , L μ , L τ ) acts similarly to a chemical potential for the neutrino flavor eigenstates and modifies neutrino oscillations. VDM imparts unique signatures such as time and directional dependence
Dawid Brzeminski, Saurav Das, Anson Hook, Clayton Ristow   +3 more
doaj   +1 more source

Interacting $p$-form gauge theories: New developments

Proceedings of The XVIth Quark Confinement and the Hadron Spectrum Conference — PoS(QCHSC24)
Gauge $p$-forms in diverse dimensions are ubiquitous in supergravity and string theory. This work reviews novel covariant formulations designed to generate arbitrary interacting duality-invariant or chiral (self-dual) $p$-form theories in $d = 2p + 2$ space-time dimensions.
openaire   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source