Results 81 to 90 of about 69,557 (255)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Discovering quirks through timing at FASER and future forward experiments at the LHC

Journal of High Energy Physics
Quirks are generic predictions of strongly-coupled dark sectors. For weak-scale masses and a broad range of confining scales in the dark sector, quirks can be discovered only at the energy frontier, but quirk-anti-quirk pairs are produced with unusual ...
Jonathan L. Feng, Jinmian Li, Xufei Liao, Jian Ni, Junle Pei   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Probing the gauge-boson couplings of axion-like particle at the LHC and high-luminosity LHC

Journal of High Energy Physics
In this work, we calculate the sensitivities on the gauge-boson couplings g aZZ , g aZγ , and g aWW of an axion-like particle (ALP) that one can achieve at the LHC with s $$ \sqrt{s} $$ = 14 TeV and integrated luminosities of 300 fb−1 (current run) and ...
Kingman Cheung, Wanyon Hsiao, C. J. Ouseph, Chen Wang   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Improving the performance of weak supervision searches using transfer and meta-learning

Journal of High Energy Physics
Weak supervision searches have in principle the advantages of both being able to train on experimental data and being able to learn distinctive signal properties.
Hugues Beauchesne, Zong-En Chen, Cheng-Wei Chiang   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Phenomenological study of heavy neutral gauge bosons in the left-right symmetric model at future muon collider

Journal of High Energy Physics
Exotic neutral gauge bosons are powerful candidates for new physics beyond the Standard Model. The Left-Right Symmetric Model is a well-motivated framework that addresses several open questions in particle physics, including neutrino masses, dark matter,
Zongyang Lu, Jianing Qin, Honglei Li, Zhi-Long Han, Fei Huang, Chun-Yuan Li, Xing-Hua Yang, Zhong-Juan Yang   +7 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Birdtracks of exotic SU(N) color structures

Journal of High Energy Physics
I introduce a systematic procedure for constructing complete and linearly independent sets of color structures for interactions of fields transforming under exotic representations of SU(N), in particular the SU(3) gauge group of QCD.
Thorsten Ohl
doaj   +1 more source