Results 81 to 90 of about 67,835 (263)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Exploring interference effects between two ALP effective operators at the LHC

Journal of High Energy Physics
We observe that most studies of axion-like particle (ALP) production channels at the Large Hadron Collider (LHC) focus on a single type of ALP operator for each process in the effective field theory framework.
Kingman Cheung, Chih-Ting Lu, C.J. Ouseph, Priyanka Sarmah   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Discovering quirks through timing at FASER and future forward experiments at the LHC

Journal of High Energy Physics
Quirks are generic predictions of strongly-coupled dark sectors. For weak-scale masses and a broad range of confining scales in the dark sector, quirks can be discovered only at the energy frontier, but quirk-anti-quirk pairs are produced with unusual ...
Jonathan L. Feng, Jinmian Li, Xufei Liao, Jian Ni, Junle Pei   +4 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Probing the gauge-boson couplings of axion-like particle at the LHC and high-luminosity LHC

Journal of High Energy Physics
In this work, we calculate the sensitivities on the gauge-boson couplings g aZZ , g aZγ , and g aWW of an axion-like particle (ALP) that one can achieve at the LHC with s $$ \sqrt{s} $$ = 14 TeV and integrated luminosities of 300 fb−1 (current run) and ...
Kingman Cheung, Wanyon Hsiao, C. J. Ouseph, Chen Wang   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Improving the performance of weak supervision searches using transfer and meta-learning

Journal of High Energy Physics
Weak supervision searches have in principle the advantages of both being able to train on experimental data and being able to learn distinctive signal properties.
Hugues Beauchesne, Zong-En Chen, Cheng-Wei Chiang   +2 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Phenomenological study of heavy neutral gauge bosons in the left-right symmetric model at future muon collider

Journal of High Energy Physics
Exotic neutral gauge bosons are powerful candidates for new physics beyond the Standard Model. The Left-Right Symmetric Model is a well-motivated framework that addresses several open questions in particle physics, including neutrino masses, dark matter,
Zongyang Lu, Jianing Qin, Honglei Li, Zhi-Long Han, Fei Huang, Chun-Yuan Li, Xing-Hua Yang, Zhong-Juan Yang   +7 more
doaj   +1 more source