Results 101 to 110 of about 20,747,688 (258)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Constraints on anomalous quartic gauge couplings via γγ and Zγ vector boson scattering at muon colliders

Journal of High Energy Physics
In the Standard Model, the couplings between gauge bosons are tightly constrained by the principles of gauge symmetry and renormalizability. However, the presence of anomalous couplings suggests the possibility of new physics beyond the Standard Model ...
M. Tekin, A. Senol, H. Denizli
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Birdtracks of exotic SU(N) color structures

Journal of High Energy Physics
I introduce a systematic procedure for constructing complete and linearly independent sets of color structures for interactions of fields transforming under exotic representations of SU(N), in particular the SU(3) gauge group of QCD.
Thorsten Ohl
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Gauge coupling unification in E 6 F-theory GUTs with matter and bulk exotics from flux breaking

, 2013
We consider gauge coupling unification in E 6 F-Theory Grand Unified Theories (GUTs) where E 6 is broken to the Standard Model (SM) gauge group using fluxes. In such models there are two types of exotics that can affect gauge coupling unification, namely
King, Stephen F., Leontaris, George K., Callaghan, James C.   +2 more
core   +1 more source

Improving the performance of weak supervision searches using data augmentation

Journal of High Energy Physics
Weak supervision combines the advantages of training on real data with the ability to exploit signal properties. However, training a neural network using weak supervision often requires an excessive amount of signal data, which severely limits its ...
Zong-En Chen, Cheng-Wei Chiang, Feng-Yang Hsieh   +2 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Semi-supervised permutation invariant particle-level anomaly detection

Journal of High Energy Physics
The development of analysis methods to distinguish potential beyond the Standard Model phenomena in a model-agnostic way can significantly enhance the discovery reach in collider experiments. However, the typical machine learning (ML) algorithms employed
Gabriel Matos, Elena Busch, Ki Ryeong Park, Julia Gonski   +3 more
doaj   +1 more source