Results 121 to 130 of about 71,229 (205)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Compound flood simulations indicate rising public exposure to sewage-contaminated waters in Waikīkī, Hawai'i. [PDF]

Sci Rep
Yamamoto K, Habel S, Son Y, Anderson TR, Obara C, Barbee MM, Fornace KL, Fletcher CH.   +7 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Amplified response of cavity-coupled quantum-critical systems. [PDF]

Nat Commun
Sur S, Wang Y, Mahankali M, Paschen S, Si Q.   +4 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Microscopic mechanism of anyon superconductivity emerging from fractional Chern insulators.

Newton
Pichler F, Kuhlenkamp C, Knap M, Vishwanath A.   +3 more
europepmc   +1 more source

The quintom theory of dark energy after DESI DR2. [PDF]

Natl Sci Rev
Cai Y, Ren X, Qiu T, Li M, Zhang X.
europepmc   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

SiMPull-POP: Quantification of Membrane Protein Assembly via Single Molecule Photobleaching. [PDF]

Bio Protoc
Schuck RJ, Ward AE, Barrera FN, Lamichhane R.   +3 more
europepmc   +1 more source