Results 121 to 130 of about 20,747,688 (258)

Minimal complete tri-hypercharge theories of flavour

Journal of High Energy Physics
The tri-hypercharge proposal introduces a separate gauged weak hypercharge assigned to each fermion family as the origin of flavour. This is arguably one of the simplest setups for building “gauge non-universal theories of flavour” or “flavour ...
Mario Fernández Navarro, Stephen F. King, Avelino Vicente   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Precision electroweak tensions and a dark photon

Journal of High Energy Physics
We examine how different assumptions about the hadronic vacuum polarization, the W boson mass, and the forward-backward asymmetry in b-quarks at the Z pole can impact the precision electroweak fit.
Keisuke Harigaya, Evan Petrosky, Aaron Pierce   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Standard Model of particle physics in other universes [PDF]

, 2005
The purpose of this paper is to demonstrate how the mathematical objects and structures associated with the particle physics in other universes, can be inferred from the mathematical objects and structures associated with the particle physics in our own ...
McCabe, Gordon, Gordon Mccabe
core  

SHIFT@LHC: Searches for new physics with shifted interaction on a fixed target at the Large Hadron Collider

Journal of High Energy Physics
New low-mass particles with very small couplings to standard model particles that travel significant distances before decaying are interesting candidates to address some of the most intriguing questions of modern physics.
Jeremi Niedziela
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Gauge theory constraints on the fermion-boson vertex [PDF]

, 1995
In this thesis we investigate the role played by fundamental properties of QED in determining the non-perturbative fermion-boson vertex. These key features are gauge invariance and multiplicative renormalisability. We use the Schwinger-Dyson equations as
Kizilersü, Ayşe, Kizilersu, A
core  

Searching for quirks at LHCb

Journal of High Energy Physics
Quirks are heavy particles connected by a flux tube from a hidden confining force that remain weakly constrained in large regions of their parameter space.
Xabier Cid Vidal, Miguel Fernández Gómez, Matthew Low, Alejandro Novo Cal, Yuhsin Tsai, Carlos Vázquez Sierra   +5 more
doaj   +1 more source