Results 111 to 120 of about 516,293 (285)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Discovering quirks through timing at FASER and future forward experiments at the LHC

Journal of High Energy Physics
Quirks are generic predictions of strongly-coupled dark sectors. For weak-scale masses and a broad range of confining scales in the dark sector, quirks can be discovered only at the energy frontier, but quirk-anti-quirk pairs are produced with unusual ...
Jonathan L. Feng, Jinmian Li, Xufei Liao, Jian Ni, Junle Pei   +4 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Probing the gauge-boson couplings of axion-like particle at the LHC and high-luminosity LHC

Journal of High Energy Physics
In this work, we calculate the sensitivities on the gauge-boson couplings g aZZ , g aZγ , and g aWW of an axion-like particle (ALP) that one can achieve at the LHC with s $$ \sqrt{s} $$ = 14 TeV and integrated luminosities of 300 fb−1 (current run) and ...
Kingman Cheung, Wanyon Hsiao, C. J. Ouseph, Chen Wang   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Improving the performance of weak supervision searches using transfer and meta-learning

Journal of High Energy Physics
Weak supervision searches have in principle the advantages of both being able to train on experimental data and being able to learn distinctive signal properties.
Hugues Beauchesne, Zong-En Chen, Cheng-Wei Chiang   +2 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Phenomenological study of heavy neutral gauge bosons in the left-right symmetric model at future muon collider

Journal of High Energy Physics
Exotic neutral gauge bosons are powerful candidates for new physics beyond the Standard Model. The Left-Right Symmetric Model is a well-motivated framework that addresses several open questions in particle physics, including neutrino masses, dark matter,
Zongyang Lu, Jianing Qin, Honglei Li, Zhi-Long Han, Fei Huang, Chun-Yuan Li, Xing-Hua Yang, Zhong-Juan Yang   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Birdtracks of exotic SU(N) color structures

Journal of High Energy Physics
I introduce a systematic procedure for constructing complete and linearly independent sets of color structures for interactions of fields transforming under exotic representations of SU(N), in particular the SU(3) gauge group of QCD.
Thorsten Ohl
doaj   +1 more source