Results 21 to 30 of about 19,612,067 (245)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A diplomacia egípcia no dealbar do «império» (século XV a. C.) [PDF]

Revista da Faculdade de Letras. Série de História, 2015
If the treaty of Kadesh (XIII B. C.) is the most evident proof of the Egyptian diplomacy, it does not summarize the subject within the pharaonic history. If on XV B.
Daniela Martins
doaj  

Complete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background For patients with ST‐segment–elevation myocardial infarction (STEMI) and multivessel coronary artery disease, the optimal treatment of the non‐infarct‐related artery has been controversial.
Yousif Ahmad, James P. Howard, Ahran Arnold, Megha Prasad, Henry Seligman, Christopher M. Cook, Takayuki Warisawa, Matthew Shun‐Shun, Ziad Ali, Manish A. Parikh, Rasha Al‐Lamee, Sayan Sen, Darrel Francis, Jeffrey W. Moses, Martin B. Leon, Gregg W. Stone, Dimitri Karmpaliotis   +16 more
doaj   +1 more source

Non-royal Nubian Clothing Representations during the New Kingdom and the Kushites Twenty-Fifth Dynasty [PDF]

International Journal of Tourism and Hospitality Management, 2018
There are interconnections between Egypt and Nubia since the Predynastic Period. The non-royal Nubians- as soldiers, servants, officials- were represented in the art of the New Kingdom in various artistic media.
Ahmed Ebied, Tamer Fahim
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Renewing the Narrative of the Age to Come: The Kingdom of God in NT Wright and John Zizioulas

Religions, 2021
This paper makes use of leading New Testament scholar NT Wright’s presentation of the biblical understanding of the kingdom to assess—on the basis of Orthodox Christian theologian John Zizioulas’ own critique—the Orthodox liturgical enactment of the ...
Geoffrey Ready
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Modius and «The Floral Crown» in the Iconography of Royal Women of the New Kingdom: Interpretation of the Symbolic Meaning of Headgears

RUDN Journal of World History, 2012
The article examines the typology of crowns of Egyptian royal woman of the New Kingdom Period (XVIII-XX dynasties) - the so-called «modius» and the «floral crown».
V Anatol'evich Bolshakov
doaj