Results 21 to 30 of about 636,540 (259)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Sexually Dimorphic Faciometrics in Humans From Early Adulthood to Late Middle Age: Dynamic, Declining, and Differentiated

Evolutionary Psychology, 2017
Faciometrics have widely been used in contemporary studies on gender-related behavioral traits, for example, perceived and actual aggression, co-operation and trustworthiness, prejudicial beliefs, unethical behavior, and achievement drive, as well as ...
Julia M. Robertson, Barbara E. Kingsley, Gina C. Ford   +2 more
doaj   +1 more source

Real-World Treatment Patterns and Clinical Outcomes in Patients Receiving Palbociclib for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced or Metastatic Breast Cancer in Argentina: The IRIS Study

Journal of Global Oncology, 2019
PURPOSE: The selective cyclin-dependent kinase 4/6 inhibitor palbociclib was approved in Argentina in 2015 for postmenopausal women with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer (ABC)
John Waller, Debanjali Mitra, Katie Mycock, Gavin Taylor-Stokes, Gary Milligan, Lin Zhan, Shrividya Iyer   +6 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A Comparison of Artificial Intelligence and Human Doctors for the Purpose of Triage and Diagnosis

Frontiers in Artificial Intelligence, 2020
AI virtual assistants have significant potential to alleviate the pressure on overly burdened healthcare systems by enabling patients to self-assess their symptoms and to seek further care when appropriate.
Adam Baker, Yura Perov, Katherine Middleton, Janie Baxter, Daniel Mullarkey, Davinder Sangar, Mobasher Butt, Arnold DoRosario, Saurabh Johri   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Food for Thought: Evaluating Dietary Documentation in Psychiatric Settings

BJPsych Open
Aims This study aims to evaluate dietary history documentation by junior doctors in a psychiatric hospital setting in Scotland. With emerging evidence in nutrition psychiatry highlighting diet's impact on mental health, especially ultra-processed foods,
Praveen Kumar, Apryl Northrup, Lorna Carroll, Heather Ireland   +3 more
doaj   +1 more source

Home-Based EEG Neurofeedback Intervention for the Management of Chronic Pain

Frontiers in Pain Research, 2022
BackgroundChronic pain and associated symptoms often cause significant disability and reduced quality of life (QoL). Neurofeedback (NFB) as part of a Brain Computer Interface can help some patients manage chronic pain by normalising maladaptive brain ...
Nick Birch, Jon Graham, Christine Ozolins, Kaushalya Kumarasinghe, Faisal Almesfer   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Impact of Smoking Bans on Clozapine Metabolism and Psychiatric Stability: A Case Report

BJPsych Open
Aims: A patient with a diagnosis of schizo-affective disorder, characterized by a history of harmful substance use, was undergoing treatment in the Intensive Psychiatric Care Unit (IPCU).
Praveen Kumar, Caio Bezzerraculas, Ananya Santosh, Nikki Thomson   +3 more
doaj   +1 more source