Results 31 to 40 of about 645,323 (260)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The Impact of Smoking Bans on Clozapine Metabolism and Psychiatric Stability: A Case Report

BJPsych Open
Aims: A patient with a diagnosis of schizo-affective disorder, characterized by a history of harmful substance use, was undergoing treatment in the Intensive Psychiatric Care Unit (IPCU).
Praveen Kumar, Caio Bezzerraculas, Ananya Santosh, Nikki Thomson   +3 more
doaj   +1 more source

Lord of The Crowns: A New Precious in the Kingdom of Clustomesogens [PDF]

Angewandte Chemie International Edition, 2018
AbstractReplacing pure inorganic materials by functional organic–inorganic hybrid ones to lower production costs has become a major challenge, in particular for the optoelectronic industry. Adding nanostructuration abilities meanwhile preserving homogeneity is even more challenging for this class of new materials.
Guy, Kevin, Ehni, Philipp, Paofai, Serge, Roiland, Claire, Amela-Cortes, Maria, Cordier, Stéphane, Laschat, Sabine, Molard, Yann, Forschner, Robert   +8 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Modius and «The Floral Crown» in the Iconography of Royal Women of the New Kingdom: Interpretation of the Symbolic Meaning of Headgears

RUDN Journal of World History, 2012
The article examines the typology of crowns of Egyptian royal woman of the New Kingdom Period (XVIII-XX dynasties) - the so-called «modius» and the «floral crown».
V Anatol'evich Bolshakov
doaj  

Adapting to Smoke-Free Psychiatric Care: An Audit of Patient Behaviour, Medication Management, and Staff Challenges

BJPsych Open
Aims: The audit conducted at New Craig’s Psychiatric Hospital’s Intensive Psychiatric Care Unit (IPCU) aimed to evaluate the impact of the Smoke-Free Perimeter Law on patient care and staff well-being. It sought to understand how the law affected patient
Praveen Kumar, Caio Bezzerraculas, Ananya Santosh, Nikki Thomson   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The Smoke-Free Law’s Toll on Intensive Psychiatric Care Unit (IPCU) Staff

BJPsych Open
Aims: This survey aimed to evaluate the impact of the Smoke-Free Perimeter Law on the staff working in the IPCU at New Craig’s Psychiatric Hospital. It focused on understanding how the law affected staff workload, their experiences with patient care, and
Praveen Kumar, Ananya Santosh, Caio Bezzerraculas, Nikki Thomson   +3 more
doaj   +1 more source

Sexually Dimorphic Faciometrics in Black Racial Groups From Early Adulthood to Late Middle Age

Evolutionary Psychology, 2018
An increasing body of research focusing on gender-related traits has utilized faciometrics in order to consider sexual dimorphism: Aspects as diverse as social heuristics, facial attractiveness, sexual orientation, aggression, and trustworthiness have ...
Julia M. Robertson, Barbara E. Kingsley
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source