Results 41 to 50 of about 19,612,067 (245)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Adapting to Smoke-Free Psychiatric Care: An Audit of Patient Behaviour, Medication Management, and Staff Challenges

BJPsych Open
Aims: The audit conducted at New Craig’s Psychiatric Hospital’s Intensive Psychiatric Care Unit (IPCU) aimed to evaluate the impact of the Smoke-Free Perimeter Law on patient care and staff well-being. It sought to understand how the law affected patient
Praveen Kumar, Caio Bezzerraculas, Ananya Santosh, Nikki Thomson   +3 more
doaj   +1 more source

A Comparison of Artificial Intelligence and Human Doctors for the Purpose of Triage and Diagnosis

Frontiers in Artificial Intelligence, 2020
AI virtual assistants have significant potential to alleviate the pressure on overly burdened healthcare systems by enabling patients to self-assess their symptoms and to seek further care when appropriate.
Adam Baker, Yura Perov, Katherine Middleton, Janie Baxter, Daniel Mullarkey, Davinder Sangar, Mobasher Butt, Arnold DoRosario, Saurabh Johri   +8 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

BUFFER ZONES IN ANCIENT EGYPT DURING THE NEW KINGDOM

Journal of the General Union of Arab Archaeologists
During the New Kingdom and particularly during the 18th dynasty, Egypt's military policy was drastically changed. The Hyksos occupation meant the end of Egypt's traditional indifference towards neighbors, especially those beyond the northeastern frontier.
Marwa Abed Elhameed Soliman, Georgia Xekalaki , Emad Abdel Azeem   +2 more
doaj   +1 more source

The Smoke-Free Law’s Toll on Intensive Psychiatric Care Unit (IPCU) Staff

BJPsych Open
Aims: This survey aimed to evaluate the impact of the Smoke-Free Perimeter Law on the staff working in the IPCU at New Craig’s Psychiatric Hospital. It focused on understanding how the law affected staff workload, their experiences with patient care, and
Praveen Kumar, Ananya Santosh, Caio Bezzerraculas, Nikki Thomson   +3 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Sexually Dimorphic Faciometrics in Black Racial Groups From Early Adulthood to Late Middle Age

Evolutionary Psychology, 2018
An increasing body of research focusing on gender-related traits has utilized faciometrics in order to consider sexual dimorphism: Aspects as diverse as social heuristics, facial attractiveness, sexual orientation, aggression, and trustworthiness have ...
Julia M. Robertson, Barbara E. Kingsley
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Enhancing On-Call Preparedness Among Junior Doctors in Psychiatry: A Comprehensive Bootcamp Approach

BJPsych Open
Aims The Psychiatry Bootcamp at a psychiatric hospital was developed to address the unique and diverse challenges faced by new trainees, including Foundation Year Doctors, General Practitioner Specialty Trainees, Core Psychiatry trainees and Broad-Based
Ananya Santosh, Praveen Kumar, Susan Brown   +2 more
doaj   +1 more source