Results 41 to 50 of about 2,627,368 (309)

New Zealand designs law: The case for reform [PDF]

open access: yes, 2009
This article is about New Zealand designs law, considered in an international and comparative context. It argues that New Zealand designs law is unsustainable and in need of reform.
Kingsbury, Anna
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

The Impact of Smoking Bans on Clozapine Metabolism and Psychiatric Stability: A Case Report

open access: yesBJPsych Open
Aims: A patient with a diagnosis of schizo-affective disorder, characterized by a history of harmful substance use, was undergoing treatment in the Intensive Psychiatric Care Unit (IPCU).
Praveen Kumar   +3 more
doaj   +1 more source

Pathway Analysis to Determine Factors Contributing to Overall Quality Scores in Four Berry Crops

open access: yesJournal of Horticultural Research, 2020
Fruit quality attributes are influenced by environmental, agronomic and genetic factors; both cultivars and growing conditions can vary substantially between UK production and imported fruit. This study aimed to record and dissect the most relevant fruit
Cockerton Helen   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Adapting to Smoke-Free Psychiatric Care: An Audit of Patient Behaviour, Medication Management, and Staff Challenges

open access: yesBJPsych Open
Aims: The audit conducted at New Craig’s Psychiatric Hospital’s Intensive Psychiatric Care Unit (IPCU) aimed to evaluate the impact of the Smoke-Free Perimeter Law on patient care and staff well-being. It sought to understand how the law affected patient
Praveen Kumar   +3 more
doaj   +1 more source

Sexually Dimorphic Faciometrics in Black Racial Groups From Early Adulthood to Late Middle Age

open access: yesEvolutionary Psychology, 2018
An increasing body of research focusing on gender-related traits has utilized faciometrics in order to consider sexual dimorphism: Aspects as diverse as social heuristics, facial attractiveness, sexual orientation, aggression, and trustworthiness have ...
Julia M. Robertson, Barbara E. Kingsley
doaj   +1 more source

Eskatologie en koninkryk in die Markusevangelie

open access: yesHTS Teologiese Studies/Theological Studies, 2008
Eschatology and kingdom in Mark This article investigates the concepts of eschatology and kingdom in Mark from a narratological point of view. Special attention is given to the narrator’s use of story time and plotted time, the narrative function of ...
Ernest van Eck
doaj   +1 more source

Contribution to the Odonata of the Kingdom of Tonga [PDF]

open access: yes, 2013
New data on the Odonata fauna of the Kingdom of Tonga is provided following re-search carried out on Tongatapu and 'Eua islands in July 2012. New localities for Tongatapu Island are put on record and previous studies are compared with new pheno-logical ...
Marinov, Milen
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

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