Results 121 to 130 of about 93,480 (289)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The marine spider, Desis marina (Araneae: Desidae): new observations and localities
, 2017 The marine spider, Desis marina (Hector, 1877), is endemic to New Zealand and lives in the intertidal zone. Despite this spider having such a fascinating habitat and biology, there have been few records of D. marina since it was first documented. Here we
Simpson, Angela +3 more
core
Records of new localities and hosts for crustacean parasites in fish from the eastern Amazon in northern Brazil. [PDF]
J Parasit Dis, 2017 Oliveira MSB +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
New localities for argentine freshwater fishes. I
, 1980 Four species of Characiformes and five species of Siluriformes are recorded from ten new argentine localities. New distributional data are discussed. Relevant morphological measurements and some comments are added.Instituto de Limnología "Dr.
López, Hugo Luis +3 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Taxonomic status and new localities for Ganoderma ravenelii
, 2008 The taxonomic status of Ganoderma ravenelii is discussed; furthermore, the species is recorded from two new localities in the USA and probably from Mexico.
Guzman-Davalos, L. +1 more
core
Track localities and sedimentary environments of dinosaur track localities in the Tremp Formation.
, 2013 Table includes new localities and data from sites previously reported in the literature. See Text S1 and Dataset S1 for further description of the localities and repositories.
Oriol Oms (381969) +6 more
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source