Results 131 to 140 of about 93,480 (289)
New localities for Argentine fresh water fishes, lI [PDF]
, 1981 Eight species of Characiformes (Aphyocharax alburnus, A. dentatus, Cheirodon leuciscus, C/i. piaba, Bryconame- ru us ihermgi, Cdandulocauda terojali, Hemiodus orthonops ami Leporinus striatus) and twc species of Siluriformes (Plat yd oras costatus and ...
Arámburu, Raúl Horacio +3 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Social Justice and Localities: the Allocation of Council Housing in Tower Hamlets
, 2004 PhDThis thesis is concerned with social justice in the distribution of social goods from public institutions. It seeks to determine applicable theoretical perspectives of social justice suitable for allocating council housing.
Lowe, Jennifer Maureen
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
New localities for Argentrne fresh water fishes, l
, 1980 Four species of Characiformes (Astyanax eigenmanniorum, Characidium rachowi, Curimatopsis saladensis and Pseudocurimata nitens) and five species of Siluriformes (Hypophthalmus edentatus, Megalodoras laevigatulus, Homodiaetus maculatus, Cataphractos ...
Arámburu, Raúl Horacio +3 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Journal of BioScience and Biotechnology, 2019 This is the check list of the ground beetles (Coleoptera: Carabidae) captured in different localities in the Western Rhodope Mts. in the period 2014 – 2017. A total of 133 species were found, including 16 endemic (12% of all), 5 relicts and 10 new for
Teodora Marius Teofilova
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source