Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
New localities for Argentrne fresh water fishes, l
, 2016 Four species of Characiformes (Astyanax eigenmanniorum, Characidium rachowi, Curimatopsis saladensis and Pseudocurimata nitens) and five species of Siluriformes (Hypophthalmus edentatus, Megalodoras laevigatulus, Homodiaetus maculatus, Cataphractos ...
Arámburu, Raúl Horacio +3 more
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Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
New localities of coarsely crystalline cryogenic cave carbonates in Slovakia
, 2013 Three new localities of coarsely crystalline cryogenic cave carbonates (CCCcoarse) have been recently discovered in the Western Carpathians, Slovakia. CCCcoarse are secondary mineral formations in the cave and belong to speleothems.
Orvošová, M.
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Kordosia, a new genus for some Late Miocene Amblycoptini shrews (Mammalia, Insectivora)
, 1997 A very rich and weil preserved Late Turolian soricid material (formerly named Amblycoptus topali JÁNOSSY 1972) is described, which have been found in Polgárdi quarry, Locality 5.
Mészáros, L. Gy.
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Understanding how mobility and spatial disparities shape COVID-19 transmission under rotational and localized lockdowns. [PDF]
Sci RepSantos-Vega M +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
New fossil evidence from the Late Cretaceous of Europe (southern France) deepens the origin of Salamandridae (Urodela) and refines the biogeography of the family. [PDF]
Sci RepMacaluso L +6 more
europepmc +1 more source