Results 101 to 110 of about 4,232,965 (395)

Resources for Media Literacy: Mediating the Research on Children and Media [PDF]

, 2012
Mucho se ha investigado sobre la educación en medios, su importancia y objetivos. Más allá de las directivas, resoluciones o recomendaciones, la investigación en esta área ha permitido profundizar y solidificar sus fundamentos, al tiempo que ha ...
Pereira, Luis, Pereira, Sara, Pinto, Manuel   +2 more
core   +4 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Digital culture in the light of educational processes. Ad vocem for the remarks and musings of Jordan Shapiro concerning the digital childhood [PDF]

Studia z Teorii Wychowania
Digital technologies not only reshape the ways we experience the world but also redefine intergenerational relationships and fundamental educational mechanisms.
Łukasz Androsiuk, Małgorzata Obrycka
doaj   +1 more source

Australia-Papua New Guinea emerging leaders dialogue: outcomes report [PDF]

Presents the outcomes of a dialogue involving twenty-two emerging leaders from Papua New Guinea and Australia, from across the business, government, media and non-government sectors.
Jenny Hayward-Jones
core  

Seen But Seldom Heard: Creative Participatory Methods in a Study of Youth and Risk [PDF]

, 2011
This paper presents a discussion of the methodologies used in a small scale ‘popular education’ project involving young people in creative activities. The goal of the project is to explore their experiences and feelings about risk and safety and their ‘
Cutts, Wendy, Fenge, Lee-Ann, Hodges, Caroline E.M.   +2 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Volleyball technical action recognition based on CNN-LSTM

Discover Artificial Intelligence
As the artificial intelligence and sensing technology rapid develop, accurate recognition of complex sports such as volleyball is greatly significant for improving training efficiency and event analysis.
Zhigang Zhang, Yong Tian, Jinchong Qi
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A Call for Change: The Evolution of the Modern Documentary from Informative Media to Persuasive Platform [PDF]

, 2011
In the past several years, new documentaries have begun to evolve from informative media to persuasive platform as a result of changing cultural contexts and ideologies.
England, Valerie
core   +1 more source