Results 91 to 100 of about 5,290,284 (268)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
How does digital transformation improve new product development performance from the perspective of resource orchestration?-Analysis based on configuration. [PDF]
PLoS One, 2023 Zhang D, Hou X, Guo J.
europepmc +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Knowledge-sharing hostility, knowledge manipulation, and new product development performance. [PDF]
Front Psychol, 2022 Cai R, Ma Y.
europepmc +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Nutritional priorities, practices and preferences of athletes and active individuals in the context of new product development in the sports nutrition sector. [PDF]
Front Sports Act Living, 2023 Carey CC, Doyle L, Lucey A.
europepmc +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
تحقیقات بازار یابی نوین, 2014 New products are critical and undeniable factors for companies that operate in a competitive and changing environment. Many researchers have sought to identify factors that affect the success of new product. This research seeks to identify and categorize
Hamid raza Rezvani +1 more
doaj
Journal of Cancer Research and Clinical OncologyPurpose This randomized, open-label, two-arm, parallel-group, single dose, multi-center phase I study (ClinicalTrials.gov ID, NCT05275010) investigated the comparability of the pharmacokinetics of a new formulation combining pertuzumab (P) and ...
Chris Wynne +7 more
doaj +1 more source