Results 101 to 110 of about 5,313,232 (289)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Pharmacokinetic bioequivalence of the fixed-dose combination of pertuzumab and trastuzumab administered subcutaneously using a handheld syringe or an on-body delivery system

Journal of Cancer Research and Clinical Oncology
Purpose This randomized, open-label, two-arm, parallel-group, single dose, multi-center phase I study (ClinicalTrials.gov ID, NCT05275010) investigated the comparability of the pharmacokinetics of a new formulation combining pertuzumab (P) and ...
Chris Wynne, Bei Wang, Rong Deng, Junyi Li, Daniel Eiger, Fabiola Bene Tchaleu, Sarah Heeson, Eleonora Restuccia   +7 more
doaj   +1 more source

The role of alliance management, big data analytics and information visibility on new-product development capability. [PDF]

Ann Oper Res, 2021
Dubey R, Bryde DJ, Graham G, Foropon C, Kumari S, Gupta O.   +5 more
europepmc   +1 more source

What is the new paradigm in product quality? [PDF]

, 2000
The current product quality paradigm is founded upon a customer-focused product development process, in which the functionality and behaviour of a product are designed to fulfil the needs of customers, and technological innovation is used to expand the ...
Guldbrandsen, M, Robotham, AJ
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Correction: Unpacking the importance of intangible skills in new product development and sustainable business performance; strategies for marketing managers. [PDF]

PLoS One, 2021
Ali S, Li G, Yang P, Hussain K, Latif Y.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Novel PBM for Nanomilling of Drugs in a Recirculating Wet Stirred Media Mill: Impacts of Batch Size, Flow Rate, and Back-Mixing

Pharmaceutics
We examined the evolution of fenofibrate (FNB, drug) particle size distribution (PSD) during the production of nanosuspensions via wet stirred media milling (WSMM) with a cell-based population balance model (PBM).
Hamidreza Heidari, Nontawat Muanpaopong, Gulenay Guner, Helen F. Yao, Donald J. Clancy, Ecevit Bilgili   +5 more
doaj   +1 more source

Product Creativity as an Identity Issue: Through the Eyes of New Product Development Team Members. [PDF]

Front Psychol, 2021
Park JS, Suzuki S.
europepmc   +1 more source

New product development in business to business marketing - a relational perspective. [PDF]

Market position and long-term competitive advantages are dependent on companies’ ability to innovate and their capacity to launch new product or services.
Filip, Alina
core   +1 more source