Results 111 to 120 of about 5,305,995 (318)

The Marketing-product Development Interface - Information Acquisition for Product Development - [PDF]

open access: yes
In the traditional company marketing approach, marketing people concentrated on how to sell the enormous volume of products, and how to achieve specific quotas based on the human relationships with clients built up by individual salesmen.
Munehiko Itoh
core  

Innovation, design and CAE in new product development [PDF]

open access: yes, 2000
There seems to be a need for clarification on a number of issues that are seminal for the design community: for example, the constructs of invention, of creativity and of innovation (or innovative) appear to be used interchangeably.
Gill, Harry, Unver, Ertu
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The Role of Technology Support Centres in stimulating Entrepreneurship and Innovation in SME Clusters [PDF]

open access: yes, 2006
The Innovative Product Development Centre (IPDC) was established at the University of Wolverhampton in the West Midlands region of the UK with a mission “to help small and medium sized companies improve their business, secure jobs and contribute to the ...
Gatcha, J, Robotham, AJ
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Diagnosing risks in new product development [PDF]

open access: yes
new product ...
Keizer, J.A., Vos, J.P.
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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