FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Modified Stage-Gate: A Conceptual Model of Virtual Product Development Process [PDF]
, 2009 In today’s dynamic marketplace, manufacturing companies are under strong pressure to introduce new products for long-term survival with their competitors.
Ahmed, Shamsuddin +2 more
core +4 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Areview on Human Capital, Organizational Learning Capability and New Product Development Performance Efficiency in Automobile Industry [PDF]
پژوهشهای مدیریت عمومی, 2014 The purpose of this paper is to investigate the relationship between human capital (HC) and new product development performance (NPDP) efficiency and in this relationship, organizational learning capability (OLC) is a mediator.
doaj +1 more source
A novel extension of Pythagorean fuzzy MULTIMOORA approach for new product development. [PDF]
Heliyon, 2023 Göçer F, Büyüközkan G.
europepmc +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
How does digital transformation improve new product development performance from the perspective of resource orchestration?-Analysis based on configuration. [PDF]
PLoS One, 2023 Zhang D, Hou X, Guo J.
europepmc +1 more source