Results 81 to 90 of about 5,290,284 (268)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Innovation, design and CAE in new product development [PDF]
, 2000 There seems to be a need for clarification on a number of issues that are seminal for the design community: for example, the constructs of invention, of creativity and of innovation (or innovative) appear to be used interchangeably.
Gill, Harry, Unver, Ertu
core
Multiobjective strategies for New Product Development in the pharmaceutical industry [PDF]
, 2012 New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline.
Azzaro-Pantel, Catherine +2 more
core +3 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Areview on Human Capital, Organizational Learning Capability and New Product Development Performance Efficiency in Automobile Industry [PDF]
پژوهشهای مدیریت عمومی, 2014 The purpose of this paper is to investigate the relationship between human capital (HC) and new product development performance (NPDP) efficiency and in this relationship, organizational learning capability (OLC) is a mediator.
doaj +1 more source
SMEs and virtual R&D teams: a motive channel for relationship between SMEs [PDF]
, 2009 In today?s dynamic marketplace, manufacturing companies are under strong pressure to introduce new products for long-term survival with their competitors.
Ahmed, S. +2 more
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A novel extension of Pythagorean fuzzy MULTIMOORA approach for new product development. [PDF]
Heliyon, 2023 Göçer F, Büyüközkan G.
europepmc +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source