Results 81 to 90 of about 28,966,456 (308)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Strategic Planning and Public management Reform: The Case of Romania

Transylvanian Review of Administrative Sciences, 2015
Strategic planning is an excellent tool that local governments can (and should) use in order to deal effi ciently with change, which means that planning is an important aspect of public sector reform, arguably one of the defi ning elements of the public
Călin Emilian HINȚEA, Marius Constantin PROFIROIU, Tudor Cristian ȚICLĂU   +2 more
doaj   +4 more sources

Transforming Citizen Engagement In E- Governance Framework: A Conceptual Analysis

JAKPP (Jurnal Analisis Kebijakan dan Pelayanan Publik)
This article explores the transformative journey of citizen participation in public affairs, focusing on the evolution from traditional public administration to contemporary e-governance frameworks.
Mohamed Awad Ali Al Araby
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Between Normative Ambition and Practical Reality: The Limits of New Public Governance in Algeria

Romanian Economic Journal
The modernization of public management represents a central challenge for contemporary states, particularly in contexts where governance systems remain heavily centralized.
Sarah Bensaoula , Mohammed Soufyane Bezzar   +1 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Report of the Public Service Commission of New Hampshire.

, 1911
Report year irregular.Mode of access: Internet.Split into: Statistical report of the Public Service Commission of New Hampshire, and: Reports and orders of the Public Service Commission of the State of New Hampshire for the period ending ..
New Hampshire. Public Service Commission.
core  

Agencification and Public Sector Performance. A Systematic Comparison in 20 Countries [PDF]

, 2016
The increased establishment of semi-autonomous agencies in most countries from the 1980s on has been justified by claims of expected improvement in public sector performance.
Overman, S.P., UU LEG Research USG Public Matters, Overman, Sjors, Thiel, S. van, UU LEG Research USG Public Matters Public Governance and Management, Public Governance, van Thiel, Sandra   +6 more
core   +2 more sources

Paradigm shift from New Public Administration to New Public Management: theory and practice in Africa

The Journal for Transdisciplinary Research in Southern Africa, 2011
The African continent is facing a number of administrative crises. The recent decline of public administration on the continent has forced some African countries to re-assess their governance systems.
Shikha Vyas-Doorgapersad
doaj   +1 more source