Results 31 to 40 of about 2,361 (241)

David Foster Wallace and New Sincerity Aesthetics: A Reply to Edward Jackson and Joel Nicholson-Roberts

open access: yesOrbit, 2017
This essay responds to the critique of my work advanced by Edward Jackson and Joel Nicholson-Roberts in “White Guys: Questioning Infinite Jest’s New Sincerity,” published in Orbit in March 2017. In addition to refuting their misrepresentations of my work,
Adam Kelly
doaj   +2 more sources

American Eccentric Cinema, by Kim Wilkins

open access: yesAlphaville: Journal of Film and Screen Media, 2021
Ever since Jeffrey Sconce discovered the “smart film”—a late twentieth/early twenty-first century sensibility surfacing in the American cinema geared toward the Gen-X indie spectator—numerous studies have appeared to further delineate the typological and
Ed Cameron
doaj   +1 more source

The Concept of Sincerity in “New Drama” [PDF]

open access: yesJournal of Siberian Federal University. Humanities & Social Sciences, 2017
The article deals with the analysis of “new drama”. A large number of various texts by young playwrights, conventionally united into the so-called “new drama” movement, are distinctive with a specific semantic and pragmatic mindset, intonations, and such fictional consciousness property as sincerity.
openaire   +3 more sources

Digital Competencies and Technologies of New Sincerity in the Web 4.0 Era

open access: yesRUDN Journal of Studies in Literature and Journalism, 2021
The problem of social aggression of young people that are immersed in digital communication has become the subject of this study. The authors did not confine to the state of the depressing condition of the ethical sphere in digital communication.
Anton N. Fortunatov   +1 more
doaj   +1 more source

Cutting to the chase: microfictions, empathy and the new sincerity [PDF]

open access: yesBrno studies in English, 2018
It has become a critical consensus that microfictions (or flash fictions) are particularly suited to the age of social media. In his attempt to theorise the genre, William Nelles (2012) allows for a wide range of narrative and thematic possibilities but maintains that, because of their radical brevity, flash fictions need to renounce characterisation ...
openaire   +1 more source

Metamodern in Indonesian Literature: A Night of 1,000 Traitors by Intan Paramaditha (2023) [PDF]

open access: yesStudia Litterarum
Looking at contemporary Indonesian literature through the lenses of the novel A Night of 1,000 Traitors by Intan Paramaditha (2023), one can explore the further development of so-called late postmodernism.
Marina V. Frolova
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Sincerity After Communism

open access: yes, 2017
This book presents the compelling study of “new sincerity” as a powerful cultural practice, born in perestroika-era Russia, and how it interconnects with global social and media flows.
Ellen Rutten
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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